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GPCR

NameProstaglandin E2 receptor EP2 subtype
SpeciesRattus norvegicus (Rat)
GenePtger2
SynonymEP2 receptor
PGE receptor EP2 subtype
PGE2 receptor EP2 subtype
prostaglandin E receptor 2 (subtype EP2), 53kDa
Prostanoid EP2 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length357
Amino acid sequenceMDNSFNDSRRVENCESRQYLLSDESPAISSVMFTAGVLGNLIALALLARRWRGDTGCSAGSRTSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQTLVALAPESRACTYFAFTMTFFSLATMLMLFAMALERYLAIGHPYFYRRRVSRRGGLAVLPAIYGVSLLFCSLPLLNYGEYVQYCPGTWCFIQHGRTAYLQLYATVLLLLIVAVLGCNISVILNLIRMQLRSKRSRCGLSGSSLRGPGSRRRGERTSMAEETDHLILLAIMTITFAVCSLPFTIFAYMDETSSRKEKWDLRALRFLSVNSIIDPWVFVILRPPVLRLMRSVLCCRTSLRAPEAPGASCSTQQTDLCGQL
UniProtQ62928
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4909
IUPHAR341
DrugBankN/A

Ligand

NameCHEMBL205819
Molecular formulaC23H35NO5
IUPAC name7-[(2S)-2-[(3R)-3-hydroxy-4-[3-(methoxymethyl)phenyl]butyl]-5-oxopyrrolidin-1-yl]heptanoic acid
Molecular weight405.535
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP2.7
SynonymsSCHEMBL4996869
7-((S)-2-((R)-3-hydroxy-4-(3-(methoxymethyl)phenyl)butyl)-5-oxopyrrolidin-1-yl)heptanoic acid
BDBM50181293
Inchi KeyQRTTXLQPQIUZPS-LEWJYISDSA-N
Inchi IDInChI=1S/C23H35NO5/c1-29-17-19-8-6-7-18(15-19)16-21(25)12-10-20-11-13-22(26)24(20)14-5-3-2-4-9-23(27)28/h6-8,15,20-21,25H,2-5,9-14,16-17H2,1H3,(H,27,28)/t20-,21+/m0/s1
PubChem CID44409742
ChEMBLCHEMBL205819
IUPHARN/A
BindingDB50181293
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<3200.0 nMPMID16442794BindingDB,ChEMBL

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