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GPCR

NameGrowth hormone secretagogue receptor type 1
SpeciesRattus norvegicus (Rat)
GeneGhsr
SynonymGH-releasing peptide receptor
Ghrelin receptor
ghrelin receptor 1a
GHRP
GHS-R
[ Show all ]
DiseaseN/A for non-human GPCRs
Length364
Amino acid sequenceMWNATPSEEPEPNVTLDLDWDASPGNDSLPDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRGDAAVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKSSINT
UniProtO08725
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3278
IUPHAR246
DrugBankN/A

Ligand

NameCHEMBL332987
Molecular formulaC36H46N4O4
IUPAC name(E)-5-amino-N,5-dimethyl-N-[(2R)-1-[methyl-[(2R)-1-oxo-1-(oxolan-2-ylmethylamino)-3-phenylpropan-2-yl]amino]-3-naphthalen-1-yl-1-oxopropan-2-yl]hex-2-enamide
Molecular weight598.788
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP4.6
SynonymsBDBM50066818
SCHEMBL6325980
SCHEMBL6325987
(E)-5-Amino-5-methyl-hex-2-enoic acid methyl-[(R)-1-(methyl-{(R)-2-phenyl-1-[(tetrahydro-furan-2-ylmethyl)-carbamoyl]-ethyl}-carbamoyl)-2-naphthalen-1-yl-ethyl]-amide
Inchi KeyQRKMAIWQNUXEDA-CJLITUQLSA-N
Inchi IDInChI=1S/C36H46N4O4/c1-36(2,37)21-11-20-33(41)39(3)32(24-28-17-10-16-27-15-8-9-19-30(27)28)35(43)40(4)31(23-26-13-6-5-7-14-26)34(42)38-25-29-18-12-22-44-29/h5-11,13-17,19-20,29,31-32H,12,18,21-25,37H2,1-4H3,(H,38,42)/b20-11+/t29?,31-,32-/m1/s1
PubChem CID10579444
ChEMBLCHEMBL332987
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC5021.0 nMPMID9733496ChEMBL
Emax110.0 %PMID9733496ChEMBL

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