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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Canis lupus familiaris (Dog)
Gene	HTR2A
Synonym	5-HT-2 5-HT-2A 5-hydroxytryptamine receptor Serotonin receptor 2A
Disease	N/A for non-human GPCRs
Length	470
Amino acid sequence	MDVLFEDNAPLSPTTSSLMPSNGDPRLYGNDLNAGDANTSDAFNWTVDAENRTNLSCEGCLSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDPGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDIIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKKDAKSTDNDYSMVALGKQHSEDAPTDNINTVNEKVSCV
UniProt	O46635
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5781
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL576631
Molecular formula	C17H19N5
IUPAC name	7-benzyl-5-methyl-3,4,6,8,12-pentazatricyclo[7.5.0.02,6]tetradeca-1(9),2,4,7-tetraene
Molecular weight	293.374
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.8
Synonyms	BDBM50301292 4-Benzyl-3-methyl-7,8,9,10-tetrahyd ro-6H-1,2,3a,5,8-pentaaza-cyclohept a[e]indene
Inchi Key	BNWRHXNSEMHGSE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H19N5/c1-12-20-21-17-14-7-9-18-10-8-15(14)19-16(22(12)17)11-13-5-3-2-4-6-13/h2-6,18H,7-11H2,1H3
PubChem CID	45484663
ChEMBL	CHEMBL576631
IUPHAR	N/A
BindingDB	50301292
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1600.0 nM	PMID19646865	BindingDB,ChEMBL
Emax	36.0 %	PMID19646865	ChEMBL

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