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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Gonadotropin-releasing hormone receptor
Species	Rattus norvegicus (Rat)
Gene	Gnrhr
Synonym	luteinizing hormone-releasing hormone (LHRH) receptor luliberin receptor LHRHR LHRH receptor GNRHR1 GnRHR GnRH1 receptor GnRH-R GnRH receptor GnRH I receptor Type I GnRHR [ Show all ]
Disease	N/A for non-human GPCRs
Length	327
Amino acid sequence	MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
UniProt	P30969
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3066
IUPHAR	256
DrugBank	N/A

Ligand

Name	CHEMBL149189
Molecular formula	C27H30N2O5
IUPAC name	4-[(2R)-3-[2-[2-(3,4-dimethoxyphenyl)-1H-indol-3-yl]ethylamino]-2-hydroxypropoxy]phenol
Molecular weight	462.546
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	4.2
Synonyms	4-[(R)-2-Hydroxy-3-[2-[2-(3,4-dimethoxyphenyl)-1H-indole-3-yl]ethylamino]propoxy]phenol 4-((R)-3-{2-[2-(3,4-Dimethoxy-phenyl)-1H-indol-3-yl]-ethylamino}-2-hydroxy-propoxy)-phenol BDBM50096994
Inchi Key	BNUWTRKFLMMITA-HXUWFJFHSA-N
Inchi ID	InChI=1S/C27H30N2O5/c1-32-25-12-7-18(15-26(25)33-2)27-23(22-5-3-4-6-24(22)29-27)13-14-28-16-20(31)17-34-21-10-8-19(30)9-11-21/h3-12,15,20,28-31H,13-14,16-17H2,1-2H3/t20-/m1/s1
PubChem CID	44365598
ChEMBL	CHEMBL149189
IUPHAR	N/A
BindingDB	50096994
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3000.0 nM	PMID11229759	BindingDB,ChEMBL

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