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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	MLS001002995
Molecular formula	C21H21N3O4S2
IUPAC name	N-(4-morpholin-4-ylsulfonylphenyl)-2-quinolin-8-ylsulfanylacetamide
Molecular weight	443.536
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	2.4
Synonyms	MolPort-000-489-413 N-[4-(morpholine-4-sulfonyl)phenyl]-2-(quinolin-8-ylsulfanyl)acetamide ZINC9403200 BDBM80031 N-(4-morpholinosulfonylphenyl)-2-(8-quinolylthio)acetamide SR-01000088385 cid_4261263 MLS-0303942.0001 N-[4-(morpholin-4-ylsulfonyl)phenyl]-2-(quinolin-8-ylsulfanyl)acetamide STL362895 AC1N6K2X N-(4-morpholin-4-ylsulfonylphenyl)-2-quinolin-8-ylsulfanyl-ethanamide Oprea1_082159 N-[4-(4-morpholinylsulfonyl)phenyl]-2-(8-quinolinylthio)acetamide SR-01000088385-1 503036-56-4 HMS2758G18 N-[4-(morpholin-4-ylsulfonyl)phenyl]-2-(quinolin-8-ylthio)acetamide Z56896726 AKOS001044574 N-(4-morpholin-4-ylsulfonylphenyl)-2-quinolin-8-ylsulfanylacetamide SMR000372646 CHEMBL1382320 MCULE-9726245195 N-[4-(morpholin-4-ylsulfonyl)phenyl]-2-(8-quinolylthio)acetamide ST50134633 [ Show all ]
Inchi Key	QPVPCRMOVBLWQG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H21N3O4S2/c25-20(15-29-19-5-1-3-16-4-2-10-22-21(16)19)23-17-6-8-18(9-7-17)30(26,27)24-11-13-28-14-12-24/h1-10H,11-15H2,(H,23,25)
PubChem CID	4261263
ChEMBL	CHEMBL1382320
IUPHAR	N/A
BindingDB	80031
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	28183.8 nM	PubChem BioAssay data set	ChEMBL

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