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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	G-protein coupled receptor homolog US28
Species	Human cytomegalovirus (strain AD169) (HHV-5)
Gene	US28
Synonym	HHRF3
Disease	N/A for non-human GPCRs
Length	354
Amino acid sequence	MTPTTTTAELTTEFDYDEDATPCVFTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDHNSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVYMRYRPVKQACLFSIFWWIFAVIIAIPHFMVVTKKDNQCMTDYDYLEVSYPIILNVELMLGAFVIPLSVISYCYYRISRIVAVSQSRHKGRIVRVLIAVVLVFIIFWLPYHLTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCLLAEFRQRLFSRDVSWYHSMSFSRRSSPSRRETSSDTLSDEVCRVSQIIP
UniProt	P69332
Protein Data Bank	4xt1
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 4xt1.
BioLiP	BL0309402,BL0309403
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4259
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL372756
Molecular formula	C21H26ClNO2
IUPAC name	4-(4-chlorophenyl)-1-(4-hydroxy-4-phenylbutyl)piperidin-4-ol
Molecular weight	359.894
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	3.6
Synonyms	4-(4-Chlorophenyl)-1-(4-phenyl-4-hydroxybutyl)piperidine-4-ol 4-(4-Chloro-phenyl)-1-(4-hydroxy-4-phenyl-butyl)-piperidin-4-ol BDBM50027206
Inchi Key	QOXZWRNEYHCQOU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H26ClNO2/c22-19-10-8-18(9-11-19)21(25)12-15-23(16-13-21)14-4-7-20(24)17-5-2-1-3-6-17/h1-3,5-6,8-11,20,24-25H,4,7,12-16H2
PubChem CID	11588534
ChEMBL	CHEMBL372756
IUPHAR	N/A
BindingDB	50027206
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<100000.0 nM	PMID16190772	BindingDB,ChEMBL
IC50	<100000.0 nM	PMID16190772	BindingDB,ChEMBL

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