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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL1773279
Molecular formula	C24H32N6O4S
IUPAC name	tert-butyl 4-[[methyl-[1-(4-methylsulfonylphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]amino]methyl]piperidine-1-carboxylate
Molecular weight	500.618
Hydrogen bond acceptor	8
Hydrogen bond donor	0
XlogP	3.2
Synonyms	142894-EP2292620A2 4-({[1-(4-Methanesulfonyl-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-methyl-amino}-methyl)-piperidine-1-carboxylic acid tert-butyl ester 142894-EP2287165A2 BDBM50343457 143630-EP2287166A2 SCHEMBL389100 4-({[1-(4-Methanesulfonyl-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-methylamino}-methyl)-piperidine-1-carboxylic acid tert-butyl ester 142894-EP2287166A2 143630-EP2292620A2 tert-butyl 4-((methyl(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)methyl)piperidine-1-carboxylate [ Show all ]
Inchi Key	QNAOVZXVOZZSTA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H32N6O4S/c1-24(2,3)34-23(31)29-12-10-17(11-13-29)15-28(4)21-20-14-27-30(22(20)26-16-25-21)18-6-8-19(9-7-18)35(5,32)33/h6-9,14,16-17H,10-13,15H2,1-5H3
PubChem CID	53630395
ChEMBL	CHEMBL1773279
IUPHAR	N/A
BindingDB	50343457
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	11.6 nM	PMID21444206	BindingDB,ChEMBL
Emax	89.0 %	PMID21444206	ChEMBL

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