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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameCHEMBL1829153
Molecular formulaC16H13ClN2O2
IUPAC name3-[4-[2-(2-chloro-6-methylpyrimidin-4-yl)ethynyl]phenyl]propanoic acid
Molecular weight300.742
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP3.4
SynonymsBDBM50419161
Inchi KeyBNLHRAHBMGBALX-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H13ClN2O2/c1-11-10-14(19-16(17)18-11)8-6-12-2-4-13(5-3-12)7-9-15(20)21/h2-5,10H,7,9H2,1H3,(H,20,21)
PubChem CID54757622
ChEMBLCHEMBL1829153
IUPHARN/A
BindingDB50419161
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC502754.23 nMPMID21854074BindingDB,ChEMBL
Efficacy110.0 %PMID21854074ChEMBL

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