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Name | 5-hydroxytryptamine receptor 1E |
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Species | Homo sapiens (Human) |
Gene | HTR1E |
Synonym | 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 5-HT1Ealpha 5-ht1e receptor 5-HT1E 5-HT-1E [ Show all ] |
Disease | N/A |
Length | 365 |
Amino acid sequence | MNITNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAALMILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRCREHT |
UniProt | P28566 |
Protein Data Bank | N/A |
GPCR-HGmod model | P28566 |
3D structure model | This predicted structure model is from GPCR-EXP P28566. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2182 |
IUPHAR | 4 |
DrugBank | BE0000476 |
Name | SB 206553 |
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Molecular formula | C17H16N4O |
IUPAC name | 1-methyl-N-pyridin-3-yl-6,7-dihydropyrrolo[2,3-f]indole-5-carboxamide |
Molecular weight | 292.342 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 1 |
XlogP | 1.7 |
Synonyms | C11740 GTPL189 NCGC00015917-04 SB-206553 hydrochloride hydrate Tocris-1661 [ Show all ] |
Inchi Key | QJQORSLQNXDVGE-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C17H16N4O/c1-20-7-4-12-10-16-13(9-15(12)20)5-8-21(16)17(22)19-14-3-2-6-18-11-14/h2-4,6-7,9-11H,5,8H2,1H3,(H,19,22) |
PubChem CID | 5163 |
ChEMBL | CHEMBL297784 |
IUPHAR | 189 |
BindingDB | 50060417 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | >5011.87 nM | PMID7629791 | ChEMBL |
Ki | 5011.87 nM | PMID8821530 | PDSP,BindingDB |
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