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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Neuropeptide Y receptor type 1
Species	Homo sapiens (Human)
Gene	NPY1R
Synonym	neuropeptide Y receptor type 1 NPY-Y1 receptor NPY1-R FC5 Y1 receptor Y1-R [ Show all ]
Disease	Hypertension; Obesity; Heart disease Obesity Eating disorders reduction in food intake obesity anxiety Eating disorders reduction in food intake Eating disorder Cardiovascular disorder Hypertension [ Show all ]
Length	384
Amino acid sequence	MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
UniProt	P25929
Protein Data Bank	5zbh
GPCR-HGmod model	P25929
3D structure model	This structure is from PDB ID 5zbh.
BioLiP	BL0411971
Therapeutic Target Database	T89213
ChEMBL	CHEMBL4777
IUPHAR	305
DrugBank	N/A

Ligand

Name	CHEMBL2397297
Molecular formula	C24H31N3O
IUPAC name	1-[6-(3-ethoxyphenyl)-3-methyl-6-bicyclo[3.1.0]hexanyl]-4-pyridin-4-ylpiperazine
Molecular weight	377.532
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.0
Synonyms	N/A
Inchi Key	BMSWYXABHIZRDE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H31N3O/c1-3-28-21-6-4-5-19(17-21)24(22-15-18(2)16-23(22)24)27-13-11-26(12-14-27)20-7-9-25-10-8-20/h4-10,17-18,22-23H,3,11-16H2,1-2H3
PubChem CID	73350551
ChEMBL	CHEMBL2397297
IUPHAR	N/A
BindingDB	50436473
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<10000.0 nM	PMID23726344	BindingDB,ChEMBL

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