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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Homo sapiens (Human)
Gene	HCAR2
Synonym	G protein-coupled receptor 109A PUMAG Nicotinic acid receptor Nic1 Niacr1 Niacin receptor 1 G-protein coupled receptor 109A G-protein coupled receptor HM74A HCA2 receptor [ Show all ]
Disease	Type 2 diabetes Hyperlipidaemia Major depressive disorder Cardiovascular disorder Atherosclerosis Arteriosclerosis Acute ischemic stroke [ Show all ]
Length	363
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProt	Q8TDS4
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS4
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS4.
BioLiP	N/A
Therapeutic Target Database	T00864
ChEMBL	CHEMBL3785
IUPHAR	312
DrugBank	BE0000635

Ligand

Name	3-phenyl-1H-pyrazole-5-carboxylic acid
Molecular formula	C10H8N2O2
IUPAC name	3-phenyl-1H-pyrazole-5-carboxylic acid
Molecular weight	188.186
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	1.7
Synonyms	MolPort-000-750-767 5-Phenyl-1H-pyrazole-3-carboxylicacid RP00181 AB0001094 ST2418848 AC1Q1HF3 Z104442688 AKOS000263428 BDBM50241312 CTK0H8940 FT-0678418 J-513035 MCULE-7695606156 3-phenyl-1H-pyrazol-2-ium-5-carboxylate 3-Phenylpyrazole-5-carboxylic acid P80028 5-phenyl-3-pyrazole carboxylic acid SBB006941 AB08419 STK560194 ACN-001108 ALBB-006580 CCG-202902 EN002251 HMS1648H01 KS-00000YW2 1134-49-2 MLS000067411 MolPort-000-145-160 5-Phenyl-1H-pyrazole-3-carboxylic acid # Pyrazole-5-carboxylic acid, 3-phenyl- SR-01000597145 AC-26517 Y-1625 AJ-72173 BB 0219050 CHEMBL397785 F0348-3292 I14-10741 KUC107418N 1H-Pyrazole-5-carboxylicacid, 3-phenyl- NCGC00342274-01 5-phenyl-2 h-pyrazole-3-carboxylic acid RP24812 AB00463493-03 ST4123297 AC1Q747X ZERO/006131 AKOS000271465 BR-32026 CTK1H3128 FT-0713944 J-517915 MFCD01248821 4CH-012732 PS-3041 5-PHENYL-PYRAZOLE-3-CARBOXYLIC ACID SCHEMBL69492 AB1008217 TOS-BB-0266 ACN-P001041 ANW-73934 CHEBI:92735 EN300-14809 HMS2206M19 KS-00001NGY 1H-Pyrazole-3-carboxylic acid, 5-phenyl- MLS001065888 MolPort-000-183-318 5-Phenyl-1H-pyrazole-3-carboxylic acid, AldrichCPR QBPUOAJBMXXBNU-UHFFFAOYSA-N 5071-61-4 SR-01000597145-1 AC1L3RYA Y9264 AK-32026 BBL007916 CS-W022423 FS-1871 J-002966 LS-128382 3-(phenyl)-1H-pyrazole-5-carboxylic acid 3-Phenyl-1H-pyrazole-5-carboxylic acid, 97% P2021 5-Phenyl-2H-pyrazole-3-carboxylic acid S-3474 AB01334874-02 STK387518 ACN-001041 ZINC3888534 AKOS005485835 BRN 0609874 DTXSID60150398 GL-0020 KS-00000CEU MFCD05170017 MLS003585704 5-Phenyl-1H-pyrazole-3-carboxylic acid Pyrazole-3-carboxylic acid, 5-phenyl- 5-Phenylpyrazole-3-carboxylic acid SMR000124836 AB1008881 X9056 ACN-P001108 BAS 09896590 EU-0099922 HMS3356K22 KSC-20-088 1H-Pyrazole-3-carboxylicacid, 5-phenyl- [ Show all ]
Inchi Key	QBPUOAJBMXXBNU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H8N2O2/c13-10(14)9-6-8(11-12-9)7-4-2-1-3-5-7/h1-6H,(H,11,12)(H,13,14)
PubChem CID	121025
ChEMBL	CHEMBL397785
IUPHAR	N/A
BindingDB	50241312
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	>50.0 %	PMID17588745	ChEMBL

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