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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Alpha-2B adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra2b
Synonym	ADRA2L1 alpha2B-adrenoceptor alpha2B alpha2-C2 alpha-2BAR alpha-2B adrenoreceptor Alpha-2B adrenoceptor Adra-2b adrenergic receptor Adrenergic alpha2B- receptor class III ADRA2RL1 alpha-2B adrenergic receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	453
Amino acid sequence	MSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPRGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPQPVAGGVPTSAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPTWSALPRSGQGQKKGTSGATAEEGDEEDEEEVEECEPQTLPASPASVCNPPLQQPQTSRVLATLRGQVLLGKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRILCRPWTQTGW
UniProt	P19328
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL266
IUPHAR	26
DrugBank	N/A

Ligand

Name	HEAT
Molecular formula	C19H21NO2
IUPAC name	2-[[2-(4-hydroxyphenyl)ethylamino]methyl]-3,4-dihydro-2H-naphthalen-1-one
Molecular weight	295.382
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	3.8
Synonyms	BE 2254 2-(beta-(4-Hydroxyphenyl)ethylaminomethyl)tetralone 2-[[2-(4-hydroxyphenyl)ethylamino]methyl]-3,4-dihydro-2H-naphthalen-1-one BRD-A24429032-003-01-6 NCGC00024637-02 AC1L1S9R CHEMBL1515808 PDSP2_000819 1(2H)-Naphthalenone, 3,4-dihydro-2-(((2-(4-hydroxyphenyl)ethyl)amino)methyl)- BE 2254, (+-)-isomer L000762 2-Heat 40077-13-2 CAS_34772 NSC_34772 BDBM81809 CTK4I2425 SCHEMBL6413372 2-(((2-(4-Hydroxyphenyl)ethyl)amino)methyl)-3,4-dihydro-1(2H)-naphthalenone 2-[beta-(4-hydroxyphenyl)ethylaminomethyl]tetralone BE-2254 LS-177614 CHEBI:91598 PDSP1_000832 [ Show all ]
Inchi Key	PZZOEXPDTYIBPI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H21NO2/c21-17-9-5-14(6-10-17)11-12-20-13-16-8-7-15-3-1-2-4-18(15)19(16)22/h1-6,9-10,16,20-21H,7-8,11-13H2
PubChem CID	34772
ChEMBL	N/A
IUPHAR	N/A
BindingDB	81809
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	0.68 nM	PMID1656026	BindingDB

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