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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 7
Species	Homo sapiens (Human)
Gene	HTR7
Synonym	5-HT-7 Serotonin receptor 7 5-HT-X 5-HT1Y 5-HT7 GPRFO 5-HT7 receptor 5-HTx 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled [ Show all ]
Disease	Sleep disorders Schizophrenia Major depressive disorder
Length	479
Amino acid sequence	MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
UniProt	P34969
Protein Data Bank	N/A
GPCR-HGmod model	P34969
3D structure model	This predicted structure model is from GPCR-EXP P34969.
BioLiP	N/A
Therapeutic Target Database	T79062
ChEMBL	CHEMBL3155
IUPHAR	12
DrugBank	BE0000650, BE0004862

Ligand

Name	5-Carboxamidotryptamine maleate
Molecular formula	C15H17N3O5
IUPAC name	3-(2-aminoethyl)-1H-indole-5-carboxamide;(Z)-but-2-enedioic acid
Molecular weight	319.317
Hydrogen bond acceptor	6
Hydrogen bond donor	5
XlogP	None
Synonyms	HMS3261G05 SR-01000075545-3 6PED53BA7M NCGC00093788-01 C-117 CHEMBL1256863 SR-01000075545 5-Carboxamidotryptamine maleate salt, powder, >=98% (HPLC) LP00352 Tox21_500352 AKOS024458233 NCGC00261037-01 1H-Indole-5-carboxamide, 3-(2-aminoethyl)-, (2Z)-2-butenedioate (1:1) CCG-221656 EU-0100352 SR-01000075545-1 5-CT; AH-21467 MolPort-003-940-625 UNII-6PED53BA7M BN0033 SCHEMBL11363734 [ Show all ]
Inchi Key	PZQZSWAOVAMBQM-BTJKTKAUSA-N
Inchi ID	InChI=1S/C11H13N3O.C4H4O4/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10;5-3(6)1-2-4(7)8/h1-2,5-6,14H,3-4,12H2,(H2,13,15);1-2H,(H,5,6)(H,7,8)/b;2-1-
PubChem CID	11709509
ChEMBL	CHEMBL1256863
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Ki	0.3 nM	PMID22738316	ChEMBL

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