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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Urotensin-2 receptor
Species	Homo sapiens (Human)
Gene	UTS2R
Synonym	urotensin II receptor UT receptor UR-II-R UR-2-R UII-R1 SENR (sensory epithelial neuropeptide-like receptor) GPR14 G-protein coupled receptor 14 G protein-coupled receptor 14 UTR2 [ Show all ]
Disease	Asthma Diabetic nephropathy Renal failure
Length	389
Amino acid sequence	MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA
UniProt	Q9UKP6
Protein Data Bank	N/A
GPCR-HGmod model	Q9UKP6
3D structure model	This predicted structure model is from GPCR-EXP Q9UKP6.
BioLiP	N/A
Therapeutic Target Database	T49072
ChEMBL	CHEMBL3764
IUPHAR	365
DrugBank	N/A

Ligand

Name	CHEMBL377946
Molecular formula	C21H23ClN2O2
IUPAC name	[1-(4-chlorophenyl)-3-(dimethylamino)propyl] 1-methylindole-2-carboxylate
Molecular weight	370.877
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	4.9
Synonyms	N/A
Inchi Key	BMAXKTGAPQGADW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H23ClN2O2/c1-23(2)13-12-20(15-8-10-17(22)11-9-15)26-21(25)19-14-16-6-4-5-7-18(16)24(19)3/h4-11,14,20H,12-13H2,1-3H3
PubChem CID	15983325
ChEMBL	CHEMBL377946
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1380.38 nM	PMID16570919	ChEMBL
Efficacy	73.0 %	PMID16570919	ChEMBL

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