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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Mus musculus (Mouse)
Gene	Hcar2
Synonym	Protein PUMA-G Nicotinic acid receptor Nic1 Niacr1 niacin receptor 1 HCA2 receptor G-protein coupled receptor HM74A G-protein coupled receptor HM74 G-protein coupled receptor 109A G-protein coupled receptor 109 G protein-coupled receptor 109A PUMAG [ Show all ]
Disease	N/A for non-human GPCRs
Length	360
Amino acid sequence	MSKSDHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVHNWDWRFGGIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGLTIGLTVHLLYTNMMTKNGEAYLCSSFSICYNFRWHDAMFLLEFFLPLAIILFCSGRIIWSLRQRQMDRHAKIKRAINFIMVVAIVFIICFLPSVAVRIRIFWLLYKYNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRKKTLGEPDNNRSTSVELTGDPSTTRSIPGALMADPSEPGSPPYLASTSR
UniProt	Q9EP66
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4420
IUPHAR	312
DrugBank	N/A

Ligand

Name	nicotinic acid
Molecular formula	C6H5NO2
IUPAC name	pyridine-3-carboxylic acid
Molecular weight	123.111
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	0.4
Synonyms	KBioSS_001543 Nicotinamide (Niacinamide) m-Pyridinecarboxylic acid Nicotinic Acid 1.0 mg/ml in Methanol NAH Nicotinic acid, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, >=98% NCGC00016268-08 Nicotinic acid, Ph Eur Niac Niacin, United States Pharmacopeia (USP) Reference Standard FC1287 niacine HMS2097B04 nicamin HY-B0143 Nicocrisina KB-259513 Nicorol ABT-919 Pyridine-3-carbonic acid 11054-EP2280001A1 Acido nicotinico [INN-Spanish] S115 11054-EP2298772A1 Akotin SK-Niacin 11054-EP2305674A1 BCP16301 Spectrum4_000965 11054-EP2311816A1 BRN 0109591 ST097540 11054-EP2316826A1 Nicotinipca CCRIS 1902 Tox21_110337_1 1976-28-9 (aluminum salt) Nikotinsaeure Daskil WLN: T6NJ CVQ 3-Picolinic acid; Niacin; Pellagra preventive factor; Pyridine-3-carboxylic acid; Vitamin B3 NSC757241 DSSTox_CID_932 3DDB011E-F3A6-45B6-A2D2-77B2A6E8936E Pellagramin 7069-06-9 (magnesium salt) Prestwick1_000881 11054-EP2270002A1 Nicosyl Kyselina nikotinova [Czech] nicotinate MFCD00006391 Nicotinic Acid [Matrix for MALDI-TOF/MS] NCGC00016268-01 Nicotinic acid, for inorganic trace analysis, >=99.999% (metals basis) NCGC00094734-02 Nicotinic acid, SAJ special grade, >=99.5% Niacin (Nicotinic Acid), Pharmaceutical Secondary Standard; Certified Reference Material Niacinamide Astra Brand GTPL1588 Niaspan HMS3371E07 Nico-400 IDI1_000695 Nicodon KBio2_001543 11054-EP2272834A1 AC1L1AD5 Pyridine-carboxylique-3 11054-EP2292610A1 ACMC-1AS6M SBB004279 11054-EP2301923A1 anti-Pellagra vitamin SPBio_000011 11054-EP2308848A1 BIDD:GT0644 SR 4390 11054-EP2311830A1 C00253 STR00112 123574-58-3 Nicovasan CHEMBL573 TR-032523 28029-53-0 (cobalt(2+) salt) Nipellen [3H]-Nicotinic acid 3-Pyridinecarboxylicacid Oprea1_514398 DTXSID1020932 5-pyridinecarboxylic acid Peviton AB00052050 preventative factor KBio3_001569 Nicotil LS-2334 Nicotinic acid (JP17/INN) N0082 Nicotinic acid, >=99.5% (HPLC) NCGC00016268-04 Nicotinic acid, meets USP testing specifications NCI60_001041 Nicotinic Acid,(S) Niacin [USAN] EPA Pesticide Chemical Code 056701 Niacinamide Pharmagenix Brand HMS1920P17 Nicacid HMS502C17 nicocap J-523605 Niconat PVNIIMVLHYAWGP-UHFFFAOYSA-N 11054-EP2275401A1 Acide nicotinique [INN-French] Pyridylcarboxylic Acid 11054-EP2295424A1 AK-46486 SCHEMBL1433 11054-EP2301937A1 Apelagrin Spectrum2_000006 11054-EP2308874A1 BP-21419 SR-01000722017-3 11054-EP2316458A1 Caswell No. 598 Tinic Nikasan D00049 Vitaplex N 3-Carboxypyridine NSC-757241 Direktan 36321-41-2 (ammonium salt) pellagra Efacin 59-67-6 PP Factor 11054-EP2269610A2 AB00052050_15 Nicosan 3 KSC236Q9T Nicotinamide (TN) MCULE-3788394698 Nicotinic acid [INN:BAN] Naotin Nicotinic acid, certified reference material, TraceCERT(R) NCGC00016268-09 Nicotinic acid, plant cell culture tested niacin Niacin-Vitamin B3 FT-0082580 Niacor HMS2236A05 Nicangin I02-0699 Nicodan KB-33243 AC-22484 Pyridine-3-carboxylic acid 11054-EP2289510A1 Acidum nicotinicum s1744 11054-EP2298776A1 AM81316 Slo-niacin 11054-EP2308838A1 BDBM23515 Spectrum5_001287 11054-EP2311817A1 BSPBio_000662 ST2413625 11054-EP2316827A1 Nicotinsaure CHEBI:15940 Tox21_201420 NINDS_000695 Davitamon PP Z56755709 3-pyridine carboxylic acid Nyclin DSSTox_GSID_20932 3PyrCOOH Pellagrin 823-77-8 (calcium salt) Prestwick2_000881 11054-EP2270014A1 Nicotamin L001199 Nicotine acid MLS000069603 Nicotinic acid, 99.5% NCGC00016268-02 Nicotinic acid, for synthesis, 99% NCGC00256537-01 Nicotinic acid, specified according to the requirements of Ph. Eur Niacin (TN) EINECS 200-441-0 Niacinamide Jenapharm Brand GTPL1594 Niaspan (TN) HMS3655K08 Nico-Span InChI=1/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9 nicolar KBio2_004111 11054-EP2272848A1 AC1Q73P3 Pyridine-carboxylique-3 [French] 11054-EP2295406A1 AI3-18994 SBI-0051456.P003 11054-EP2301929A1 antipellagra vitamin SPBio_002881 11054-EP2308854A1 Bionic SR-01000722017 11054-EP2314588A1 C6H5NO2 SW197229-3 1580002-26-1 Nicovasen CPD000059024 UNII-2679MF687A 28029-54-1 (manganese(2+) salt) NSC 169454 DB00627 [3H]nicotinic acid 3-Pyridyl carboxylic acid P.P. factor EBD2198325 53890-72-5 (lithium salt) Pharmagenix Brand of Niacinamide .beta.-Pyridinecarboxylic acid AB00052050-13 PS-4255 KBioGR_001309 Nicotinamide (JP15/INN) M-5918 Nicotinic acid (Vitamin B3) solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material N1103 Nicotinic acid, analytical standard NCGC00016268-05 Nicotinic acid, NIST(R) SRM(R) 148 Ncotnc acd Niacin [USP] F2191-0082 Niacinamide, Nicotinic acid amide, Nicotinamide HMS2091H22 Nicagin HSDB 3134 Nicocidin Jenapharm Brand of Niacinamide Niconazid AB1002056 Pyridine-.beta.-carboxylic acid 11054-EP2277848A1 Acido nicotinico RP00705 11054-EP2298742A1 AKOS000118980 SDCCGMLS-0066610.P001 11054-EP2305651A1 Astra Brand of Niacinamide Spectrum3_000515 11054-EP2311808A1 BPBio1_000730 SR-01000722017-4 11054-EP2316825A1 Nicotinic acid-d3(major) CCG-38340 Tox21_110337 16518-17-5 (potassium salt) Nikazan D06NVJ wampocap 3-Picolinic acid NSC169454 DivK1c_000695 3789-96-6 (tartrate) Pellagra preventive factor 636-79-3 (hydrochloride) Prestwick0_000881 11054-EP2269990A1 Nicoside Kyselina nikotinova Nicotinamide-carbonyl-14C Merck Brand of Niacinamide Nicotinic acid [INN] NC00524 Nicotinic acid, European Pharmacopoeia (EP) Reference Standard NCGC00094734-01 Nicotinic acid, purum, >=99.0% (HPLC) Niacin (nicotinic acid) Niacinamide (TN) FT-0600004 Niacor (TN) HMS3259K21 NICO I14-92791 Nicodelmine KBio1_000695 AC-907/25014105 Pyridine-beta-carboxylic acid 11054-EP2292228A1 Acidum nicotinicum [INN-Latin] SAM002554917 11054-EP2298779A1 AN-23622 SMR000059024 11054-EP2308839A1 beta-pyridinecarboxylic acid Spectrum_001063 11054-EP2311829A1 BSPBio_002069 STK301803 11054-EP2316828A1 Nicotinsaure [German] Tox21_302904 2679MF687A NIO DB-007765 ZINC1795 3-pyridinecarboxylic acid Opera_ID_1346 DSSTox_RID_75875 5-22-02-00057 (Beilstein Handbook Reference) Pelonin 99148-57-9 (tosylate) Prestwick3_000881 11054-EP2272825A2 Nicotene Linic MolPort-000-142-273 Nicotinic acid, >=98% NCGC00016268-03 Nicotinic acid, matrix substance for MALDI-MS, >=99.5% (HPLC) NCGC00258971-01 Nicotinic acid, Vetec(TM) reagent grade, >=98% Niacin (USP) Enduracin Niacinamide Merck Brand HMS1570B04 NIASPAN TITRATION STARTER PACK HMS3714B04 nicobid Induracin Niconacid KBio2_006679 PubChem2594 11054-EP2274983A1 Acide nicotinique Pyridinecarboxylic acid, 3- 11054-EP2295409A1 AJ-08093 SC-05611 11054-EP2301935A1 ANW-75276 SPECTRUM1500430 11054-EP2308858A1 bmse000104 SR-01000722017-2 11054-EP2316457A1 CAS-59-67-6 Tega-Span Nicyl CS-1946 vitamin B3 3-Carboxylpyridine NSC-169454 Diacin [5, 6-3H]-niacin 3-Pyridylcarboxylic acid P.P. factor-pellagra preventive factor EC 200-441-0 54-86-4 (hydrochloride salt) Pharmakon1600-01500430 10361-13-4 (iron(2+) salt) AB00052050_14 [ Show all ]
Inchi Key	PVNIIMVLHYAWGP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
PubChem CID	938
ChEMBL	CHEMBL573
IUPHAR	1594, 1588
BindingDB	23515
DrugBank	DB00627
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	29.0 nM	PMID24900295, PMID24900372	BindingDB,ChEMBL
EC50	270.0 nM	PMID17994679	ChEMBL
IC50	140.0 nM	PMID17994679, PMID19307116, PMID20615702	BindingDB,ChEMBL

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