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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 7
Species	Rattus norvegicus (Rat)
Gene	Htr7
Synonym	GPRFO 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 5-HTx 5-HT7 receptor 5-HT7 5-HT1Y 5-HT-X 5-HT-7 Serotonin receptor 7 [ Show all ]
Disease	N/A for non-human GPCRs
Length	448
Amino acid sequence	MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
UniProt	P32305
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3223
IUPHAR	12
DrugBank	N/A

Ligand

Name	CHEMBL157840
Molecular formula	C24H29N3O4
IUPAC name	1-(2-hydroxyphenyl)-6-[4-(5-methoxy-1,2-benzoxazol-3-yl)piperazin-1-yl]hexan-1-one
Molecular weight	423.513
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	4.5
Synonyms	BDBM50123700 1-(2-Hydroxy-phenyl)-6-[4-(5-methoxy-benzo[d]isoxazol-3-yl)-piperazin-1-yl]-hexan-1-one
Inchi Key	BLJLFJSNEJZSQQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H29N3O4/c1-30-18-10-11-23-20(17-18)24(25-31-23)27-15-13-26(14-16-27)12-6-2-3-8-21(28)19-7-4-5-9-22(19)29/h4-5,7,9-11,17,29H,2-3,6,8,12-16H2,1H3
PubChem CID	11122723
ChEMBL	CHEMBL157840
IUPHAR	N/A
BindingDB	50123700
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	462.0 nM	PMID12570387	BindingDB
Ki	462.0 nM	PMID12570387	ChEMBL

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