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GPCR

NameB2 bradykinin receptor
SpeciesRattus norvegicus (Rat)
GeneBdkrb2
SynonymB2 receptor
B2BKR
B2BRA
BK-2 receptor
BK2R
[ Show all ]
DiseaseN/A for non-human GPCRs
Length396
Amino acid sequenceMDTRSSLCPKTQAVVAVFWGPGCHLSTCIEMFNITTQALGSAHNGTFSEVNCPDTEWWSWLNAIQAPFLWVLFLLAALENIFVLSVFCLHKTNCTVAEIYLGNLAAADLILACGLPFWAITIANNFDWLFGEVLCRVVNTMIYMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWSCTLLLSSPMLVFRTMKDYREEGHNVTACVIVYPSRSWEVFTNMLLNLVGFLLPLSIITFCTVRIMQVLRNNEMKKFKEVQTEKKATVLVLAVLGLFVLCWFPFQISTFLDTLLRLGVLSGCWNERAVDIVTQISSYVAYSNSCLNPLVYVIVGKRFRKKSREVYQAICRKGGCMGESVQMENSMGTLRTSISVDRQIHKLQDWAGNKQ
UniProtP25023
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2501
IUPHAR42
DrugBankN/A

Ligand

NameCHEMBL164551
Molecular formulaC22H22N4O4S2
IUPAC nameN-benzyl-3-nitro-4-[2-(3-phenylpropanethioyl)hydrazinyl]benzenesulfonamide
Molecular weight470.562
Hydrogen bond acceptor7
Hydrogen bond donor3
XlogP4.7
SynonymsBDBM50085695
N-Benzyl-3-nitro-4-[N''-(3-phenyl-thiopropionyl)-hydrazino]-benzenesulfonamide
Inchi KeyPOGDBSJQJPPCJN-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H22N4O4S2/c27-26(28)21-15-19(32(29,30)23-16-18-9-5-2-6-10-18)12-13-20(21)24-25-22(31)14-11-17-7-3-1-4-8-17/h1-10,12-13,15,23-24H,11,14,16H2,(H,25,31)
PubChem CID10790547
ChEMBLCHEMBL164551
IUPHARN/A
BindingDB50085695
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<100000.0 nMPMID10715143BindingDB,ChEMBL

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