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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Histamine H2 receptor
Species	Mus musculus (Mouse)
Gene	Hrh2
Synonym	Gastric receptor I H2 receptor H2R HH2R
Disease	N/A for non-human GPCRs
Length	397
Amino acid sequence	MEPNGTVHSCCLDSIALKVTISVVLTTLIFITVAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVMPFSAIYQLSFKWSFGQVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGMVTFYLPLLIMCVTYYRIFKIAREQAKRINHISSWKAATIREHKATVTLAAVMGAFIVCWFPYFTAFVYRGLRGDDAVNEVVEGIVLWLGYANSALNPILYATLNRDFRMAYQQLFHCKLASHNSHKTSLRLNNSLLSRSQSREGRWQEEKPLKLQVWSGTELTHPQGSPVRTRLSHSSCLLSLSLLSFIWKLGTWIHHRRPFQPSLHISA
UniProt	P97292
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2245
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	HTFMT
Molecular formula	C19H25F3N4O
IUPAC name	6-[2-(1H-imidazol-5-yl)ethylamino]-N-[4-(trifluoromethyl)phenyl]heptanamide
Molecular weight	382.431
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	3.1
Synonyms	6-[2-(1H-imidazol-5-yl)ethylamino]-N-[4-(trifluoromethyl)phenyl]heptanamide GTPL1273 L024081 BRD-A66435872-313-01-8 Histamine trifluoromethyl-toluidide 103827-16-3 CHEMBL67601 6-[2-(3H-imidazol-4-yl)ethylamino]-N-[4-(trifluoromethyl)phenyl]heptanamide Heptanamide, 6-((2-(1H-imidazol-4-yl)ethyl)amino)-N-(4-(trifluoromethyl)phenyl)- NCGC00024706-02 CHEBI:91812 histamine-trifluoromethyl-toluidine D09UVB HTMT AC1L3Z71 Histamine trifluoromethyl toluidide histamine-trifluoromethyltoluide [ Show all ]
Inchi Key	PMKJGGBYYNEYPA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H25F3N4O/c1-14(24-11-10-17-12-23-13-25-17)4-2-3-5-18(27)26-16-8-6-15(7-9-16)19(20,21)22/h6-9,12-14,24H,2-5,10-11H2,1H3,(H,23,25)(H,26,27)
PubChem CID	124846
ChEMBL	CHEMBL67601
IUPHAR	1273
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Relative potency	40000.0 -	PMID2959777	ChEMBL

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