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GLASS

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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	MLS000062663
Molecular formula	C15H9NO2S3
IUPAC name	3-(1,3-benzothiazol-2-ylsulfanyl)-1-benzothiophene 1,1-dioxide
Molecular weight	331.422
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	3.9
Synonyms	3-(1,3-benzothiazol-2-ylthio)benzothiophene 1,1-dioxide CHEMBL1370884 SR-01000499549 2-(1,1-Dioxo-1H-1lambda6-benzo[b]thiophen-3-ylsulfanyl)-benzothiazole AC1LDTDI HMS2355N03 STK089167 3-(1,3-benzothiazol-2-ylsulfanyl)-1-benzothiophene 1,1-dioxide BDBM37114 3-benzothiazol-2-ylthiobenzo[b]thiole-1,1-dione cid_701067 SR-01000499549-1 2-[(1,1-dioxido-1-benzothien-3-yl)thio]-1,3-benzothiazole AKOS000639850 MCULE-8619684140 ZINC81590 3-(1,3-benzothiazol-2-ylthio)-1-benzothiophene 1,1-dioxide SMR000071200 HMS1681I07 ST092382 2-[(1,1-dioxido-1-benzothiophen-3-yl)sulfanyl]-1,3-benzothiazole BAS 03295946 MLS-0010363.0001 [ Show all ]
Inchi Key	BKZOIKUBPIWBKV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H9NO2S3/c17-21(18)9-13(10-5-1-4-8-14(10)21)20-15-16-11-6-2-3-7-12(11)19-15/h1-9H
PubChem CID	701067
ChEMBL	CHEMBL1370884
IUPHAR	N/A
BindingDB	37114
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	1258.9 nM	PubChem BioAssay data set	ChEMBL

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