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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Homo sapiens (Human)
Gene	GHSR
Synonym	ghrelin receptor GH-releasing peptide receptor GHRP GHS-R growth hormone-releasing peptide receptor ghrelin receptor 1a [ Show all ]
Disease	N/A
Length	366
Amino acid sequence	MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProt	Q92847
Protein Data Bank	N/A
GPCR-HGmod model	Q92847
3D structure model	This predicted structure model is from GPCR-EXP Q92847.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4616
IUPHAR	246
DrugBank	BE0003383

Ligand

Name	CHEMBL2011816
Molecular formula	C32H36N4O4
IUPAC name	(2R)-N-(1-benzylpiperidin-4-yl)-2-(2,5-dioxo-7-phenoxy-1,3-dihydro-1,4-benzodiazepin-4-yl)-3-methylbutanamide
Molecular weight	540.664
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	4.7
Synonyms	BDBM50379308
Inchi Key	PLLATLJFWFCODP-SSEXGKCCSA-N
Inchi ID	InChI=1S/C32H36N4O4/c1-22(2)30(31(38)33-24-15-17-35(18-16-24)20-23-9-5-3-6-10-23)36-21-29(37)34-28-14-13-26(19-27(28)32(36)39)40-25-11-7-4-8-12-25/h3-14,19,22,24,30H,15-18,20-21H2,1-2H3,(H,33,38)(H,34,37)/t30-/m1/s1
PubChem CID	70695747
ChEMBL	CHEMBL2011816
IUPHAR	N/A
BindingDB	50379308
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	7.0 nM	PMID22305493	BindingDB
IC50	8.0 nM	PMID22305493	BindingDB,ChEMBL
Ki	4.4 nM	PMID22305493	BindingDB,ChEMBL

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