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GPCR

Name	P2Y purinoceptor 4
Species	Homo sapiens (Human)
Gene	P2RY4
Synonym	UNR pyrimidinoceptor pyrimidinergic receptor P2Y P2Y4R P2Y4 receptor P2Y4 P2Y purinoceptor 4 P2Y ATP receptor 4 P2P NRU uridine nucleotide receptor [ Show all ]
Disease	N/A
Length	365
Amino acid sequence	MASTESSLLRSLGLSPGPGSSEVELDCWFDEDFKFILLPVSYAVVFVLGLGLNAPTLWLFIFRLRPWDATATYMFHLALSDTLYVLSLPTLIYYYAAHNHWPFGTEICKFVRFLFYWNLYCSVLFLTCISVHRYLGICHPLRALRWGRPRLAGLLCLAVWLVVAGCLVPNLFFVTTSNKGTTVLCHDTTRPEEFDHYVHFSSAVMGLLFGVPCLVTLVCYGLMARRLYQPLPGSAQSSSRLRSLRTIAVVLTVFAVCFVPFHITRTIYYLARLLEADCRVLNIVNVVYKVTRPLASANSCLDPVLYLLTGDKYRRQLRQLCGGGKPQPRTAASSLALVSLPEDSSCRWAATPQDSSCSTPRADRL
UniProt	P51582
Protein Data Bank	N/A
GPCR-HGmod model	P51582
3D structure model	This predicted structure model is from GPCR-EXP P51582.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2123
IUPHAR	325
DrugBank	N/A

Ligand

Name	uridine 5'-triphosphate
Molecular formula	C9H15N2O15P3
IUPAC name	[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
Molecular weight	484.139
Hydrogen bond acceptor	15
Hydrogen bond donor	7
XlogP	-5.8
Synonyms	Uridine5'-(tetrahydrogen triphosphate) 5'-UTP [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate AN-41856 CHEBI:15713 D0Z7FU GTPL1734 KBio2_002177 NINDS_000269 Spectrum_001697 Uridine 5'-triphosphoric acid UT0S826Z60 AC1L1LV9 [[[5-(2,4-Dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid bmse000295 CS-7777 DC99D596-4755-4E87-B3AA-F1D6CFEDCE9A I14-101793 KBio3_002692 SPBio_000509 uridine 5''-triphosphoric acid uridine tetrahydrogen triphosphate 266356-22-3 5''-UTP VZ34081 AK122022 C00075 D0W1XX EINECS 200-558-7 INS316 LS-160841 Spectrum4_000851 ((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate Uridine, mono(tetrahydrogen triphosphate) (ester) uridine5'-triphosphate [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate AX8156257 DB-054470 H4utp KBio2_004745 PGAVKCOVUIYSFO-XVFCMESISA-N UNII-UT0S826Z60 Uridine 5_-triphosphate 19817-92-6 3h-uridine triphosphate Uteplex AC1Q1I4F BRN 0071520 CTK5B8994 DivK1c_000269 IDI1_000269 KBioGR_001481 Spectrum2_000525 Uridine 5'-(tetrahydrogen triphosphate) uridine triphosphate 5'-URIDYLATE TRIPHOSPHATE ZINC3861755 AKOS016011172 C9H15N2O15P3 D0Y1ZP FT-0631282 KBio1_000269 NCGC00163323-01 Spectrum5_001167 Uridine 5'-triphosphate sodium salt, AldrichCPR 063U398 uridine-5'-triphosphate uridintriphosphat 63-39-8 [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate BDBM50118213 CHEMBL336296 DB04005 HY-107372 KBio2_007313 SCHEMBL76682 uridine 5''-(tetrahydrogen triphosphate) Uridine mono(tetrahydrogen triphosphate) 2,4(1H,3H)-Pyrimidinedione, 1-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-.beta.-D-ribofuranosyl]- 4-24-00-01222 (Beilstein Handbook Reference) UTP AJ-75025 BSPBio_003192 D0W1NH DTXSID0041147 INS 316 KBioSS_002177 Spectrum3_001596 Uridine 5'-(tetrahydrogen triphosphate) (8CI,9CI) Uridine, 5'-(tetrahydrogen triphosphate) [ Show all ]
Inchi Key	PGAVKCOVUIYSFO-XVFCMESISA-N
Inchi ID	InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
PubChem CID	6133
ChEMBL	CHEMBL336296
IUPHAR	1734
BindingDB	50118213
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor.

Experimental Data

Parameter	Value	Reference	Database source
EC50	39.0 nM	PMID17079144, PMID17011188	BindingDB,ChEMBL
EC50	73.0 nM	PMID17302398	BindingDB,ChEMBL
EC50	80.0 nM	PMID21528910	BindingDB,ChEMBL
EC50	87.0 nM	PMID17125260	BindingDB,ChEMBL
EC50	88.0 nM	PMID21417463	BindingDB
EC50	88.4 nM	PMID21417463	ChEMBL
EC50	90.0 nM	PMID21528910, PMID20446735, PMID18514530	BindingDB,ChEMBL
EC50	100.0 nM	PMID11206448	BindingDB,ChEMBL
EC50	480.0 nM	PMID22107038, PMID18760862	BindingDB,ChEMBL
EC50	500.0 nM	PMID20095577	BindingDB,ChEMBL
EC50	501.187 nM	PMID10779375	IUPHAR
EC50	900.0 nM	PMID22901672	BindingDB,ChEMBL
EC50	2500.0 nM	PMID12213051	BindingDB,ChEMBL

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