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GPCR

Name	P2Y purinoceptor 11
Species	Homo sapiens (Human)
Gene	P2RY11
Synonym	P2Y11 P2Y11 receptor purinergic receptor P2Y, G-protein coupled, 11
Disease	N/A
Length	374
Amino acid sequence	MAANVSGAKSCPANFLAAADDKLSGFQGDFLWPILVVEFLVAVASNGLALYRFSIRKQRPWHPAVVFSVQLAVSDLLCALTLPPLAAYLYPPKHWRYGEAACRLERFLFTCNLLGSVIFITCISLNRYLGIVHPFFARSHLRPKHAWAVSAAGWVLAALLAMPTLSFSHLKRPQQGAGNCSVARPEACIKCLGTADHGLAAYRAYSLVLAGLGCGLPLLLTLAAYGALGRAVLRSPGMTVAEKLRVAALVASGVALYASSYVPYHIMRVLNVDARRRWSTRCPSFADIAQATAALELGPYVGYQVMRGLMPLAFCVHPLLYMAAVPSLGCCCRHCPGYRDSWNPEDAKSTGQALPLNATAAPKPSEPQSRELSQ
UniProt	Q96G91
Protein Data Bank	N/A
GPCR-HGmod model	Q96G91
3D structure model	This predicted structure model is from GPCR-EXP Q96G91.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4867
IUPHAR	327
DrugBank	BE0005499

Ligand

Name	uridine 5'-triphosphate
Molecular formula	C9H15N2O15P3
IUPAC name	[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
Molecular weight	484.139
Hydrogen bond acceptor	15
Hydrogen bond donor	7
XlogP	-5.8
Synonyms	BSPBio_003192 D0W1NH DTXSID0041147 INS 316 KBioSS_002177 Spectrum3_001596 Uridine 5'-(tetrahydrogen triphosphate) (8CI,9CI) Uridine, 5'-(tetrahydrogen triphosphate) 4-24-00-01222 (Beilstein Handbook Reference) UTP AJ-75025 AN-41856 CHEBI:15713 D0Z7FU GTPL1734 KBio2_002177 NINDS_000269 Spectrum_001697 Uridine 5'-triphosphoric acid Uridine5'-(tetrahydrogen triphosphate) 5'-UTP [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate [[[5-(2,4-Dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid bmse000295 CS-7777 DC99D596-4755-4E87-B3AA-F1D6CFEDCE9A I14-101793 KBio3_002692 SPBio_000509 uridine 5''-triphosphoric acid uridine tetrahydrogen triphosphate 266356-22-3 UT0S826Z60 AC1L1LV9 C00075 D0W1XX EINECS 200-558-7 INS316 LS-160841 Spectrum4_000851 ((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate Uridine, mono(tetrahydrogen triphosphate) (ester) 5''-UTP VZ34081 AK122022 AX8156257 DB-054470 H4utp KBio2_004745 PGAVKCOVUIYSFO-XVFCMESISA-N UNII-UT0S826Z60 Uridine 5_-triphosphate 19817-92-6 uridine5'-triphosphate [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate BRN 0071520 CTK5B8994 DivK1c_000269 IDI1_000269 KBioGR_001481 Spectrum2_000525 Uridine 5'-(tetrahydrogen triphosphate) uridine triphosphate 3h-uridine triphosphate Uteplex AC1Q1I4F C9H15N2O15P3 D0Y1ZP FT-0631282 KBio1_000269 NCGC00163323-01 Spectrum5_001167 Uridine 5'-triphosphate sodium salt, AldrichCPR 063U398 uridine-5'-triphosphate 5'-URIDYLATE TRIPHOSPHATE ZINC3861755 AKOS016011172 BDBM50118213 CHEMBL336296 DB04005 HY-107372 KBio2_007313 SCHEMBL76682 uridine 5''-(tetrahydrogen triphosphate) Uridine mono(tetrahydrogen triphosphate) 2,4(1H,3H)-Pyrimidinedione, 1-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-.beta.-D-ribofuranosyl]- uridintriphosphat 63-39-8 [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate [ Show all ]
Inchi Key	PGAVKCOVUIYSFO-XVFCMESISA-N
Inchi ID	InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
PubChem CID	6133
ChEMBL	CHEMBL336296
IUPHAR	1734
BindingDB	50118213
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<100000.0 nM	PMID12213051	BindingDB,ChEMBL
EC50	6309.57 nM	PMID12761346	IUPHAR

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