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GPCR

NameC-C chemokine receptor type 3
SpeciesHomo sapiens (Human)
GeneCCR3
SynonymMIP-1alphaRL-2 (mouse)
Eosinophil eotaxin receptor
CKR3
chemokine (C-C motif) receptor 3
CD193
[ Show all ]
DiseaseAllergic asthma
Allergic rhinitis
Asthma
Length355
Amino acid sequenceMTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
UniProtP51677
Protein Data BankN/A
GPCR-HGmod modelP51677
3D structure modelThis predicted structure model is from GPCR-EXP P51677.
BioLiPN/A
Therapeutic Target DatabaseT02752, T85228
ChEMBLCHEMBL3473
IUPHAR60
DrugBankN/A

Ligand

NameCHEMBL299385
Molecular formulaC23H27F4N3O
IUPAC name1-[3-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]propyl]-3-[2-(trifluoromethyl)phenyl]urea
Molecular weight437.483
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP5.0
SynonymsBDBM50115054
SCHEMBL6339202
1-{3-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-propyl}-3-(2-trifluoromethyl-phenyl)-urea
Inchi KeyBKGDSYCWICQSPA-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H27F4N3O/c24-19-8-6-17(7-9-19)16-18-10-14-30(15-11-18)13-3-12-28-22(31)29-21-5-2-1-4-20(21)23(25,26)27/h1-2,4-9,18H,3,10-16H2,(H2,28,29,31)
PubChem CID22393362
ChEMBLCHEMBL299385
IUPHARN/A
BindingDB50115054
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50200.0 nMPMID12067561BindingDB,ChEMBL

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