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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M5
Species	Rattus norvegicus (Rat)
Gene	Chrm5
Synonym	cholinergic receptor cholinergic receptor, muscarinic 5 M5 receptor M5R
Disease	N/A for non-human GPCRs
Length	531
Amino acid sequence	MEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPPDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEAKKREPAQRTLLRSFFSCPRPSLAQRERNQASWSSSRRSTSTTGKTTQATDLSADWEKAEQVTTCSSYPSSEDEAKPTTDPVFQMVYKSEAKESPGKESNTQETKETVVNTRTENSDYDTPKYFLSPAAAHRLKSQKCVAYKFRLVVKADGTQETNNGCRKVKIMPCSFPVSKDPSTKGPDPNLSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYWQGNSKLP
UniProt	P08911
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL277
IUPHAR	17
DrugBank	N/A

Ligand

Name	CHEMBL6482
Molecular formula	C22H28N2
IUPAC name	2-butyl-7-phenyl-1,3,4,6,7,11b-hexahydropyrazino[2,1-a]isoquinoline
Molecular weight	320.48
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	4.3
Synonyms	BDBM50028299 cis-2-Butyl-7-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline
Inchi Key	BKFAIRPZGSVHAL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H28N2/c1-2-3-13-23-14-15-24-16-21(18-9-5-4-6-10-18)19-11-7-8-12-20(19)22(24)17-23/h4-12,21-22H,2-3,13-17H2,1H3
PubChem CID	13457908
ChEMBL	CHEMBL6482
IUPHAR	N/A
BindingDB	50028299
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	18000.0 nM	PMID6747997	BindingDB,ChEMBL

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