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GPCR

NameN-arachidonyl glycine receptor
SpeciesHomo sapiens (Human)
GeneGPR18
SynonymGPCRW
G-protein coupled receptor 18
N-arachidonoyol glycine receptor
NAGly receptor
GPR18
DiseaseN/A
Length331
Amino acid sequenceMITLNNQDQPVPFNSSHPDEYKIAALVFYSCIFIIGLFVNITALWVFSCTTKKRTTVTIYMMNVALVDLIFIMTLPFRMFYYAKDEWPFGEYFCQILGALTVFYPSIALWLLAFISADRYMAIVQPKYAKELKNTCKAVLACVGVWIMTLTTTTPLLLLYKDPDKDSTPATCLKISDIIYLKAVNVLNLTRLTFFFLIPLFIMIGCYLVIIHNLLHGRTSKLKPKVKEKSIRIIITLLVQVLVCFMPFHICFAFLMLGTGENSYNPWGAFTTFLMNLSTCLDVILYYIVSKQFQARVISVMLYRNYLRSMRRKSFRSGSLRSLSNINSEML
UniProtQ14330
Protein Data BankN/A
GPCR-HGmod modelQ14330
3D structure modelThis predicted structure model is from GPCR-EXP Q14330.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2384898
IUPHAR89
DrugBankBE0002304

Ligand

NameCHEMBL3221211
Molecular formulaC13H10Cl2N2OS
IUPAC name(2Z)-2-[(2,6-dichlorophenyl)methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one
Molecular weight313.196
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP3.8
SynonymsN/A
Inchi KeyPCLSYWYZRQXVAJ-XFFZJAGNSA-N
Inchi IDInChI=1S/C13H10Cl2N2OS/c14-9-3-1-4-10(15)8(9)7-11-12(18)17-5-2-6-19-13(17)16-11/h1,3-4,7H,2,5-6H2/b11-7-
PubChem CID90667666
ChEMBLCHEMBL3221211
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity12.0 %MedChemComm, (2014) 5:5:632ChEMBL
IC50<10000.0 nMMedChemComm, (2014) 5:5:632ChEMBL
Inhibition0.0 %MedChemComm, (2014) 5:5:632ChEMBL

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