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Name | Histamine H3 receptor |
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Species | Homo sapiens (Human) |
Gene | HRH3 |
Synonym | HH3R H3R H3 receptor GPCR97 G-protein coupled receptor 97 |
Disease | Obese insulin-resistant disorders Excessive daytime sleepiness Sleep disorders Schizophrenia Pain [ Show all ] |
Length | 445 |
Amino acid sequence | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK |
UniProt | Q9Y5N1 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9Y5N1 |
3D structure model | This predicted structure model is from GPCR-EXP Q9Y5N1. |
BioLiP | N/A |
Therapeutic Target Database | T64765 |
ChEMBL | CHEMBL264 |
IUPHAR | 264 |
DrugBank | BE0000968 |
Name | CHEMBL203263 |
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Molecular formula | C15H20ClN3 |
IUPAC name | N-[(4-chlorophenyl)methyl]-5-(1H-imidazol-5-yl)pentan-1-amine |
Molecular weight | 277.796 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 2 |
XlogP | 3.1 |
Synonyms | BDBM85830 LS-193639 VUF5202 PDSP1_000283 ZINC13685907 [ Show all ] |
Inchi Key | BJZMQYYHQDWJRH-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C15H20ClN3/c16-14-7-5-13(6-8-14)10-17-9-3-1-2-4-15-11-18-12-19-15/h5-8,11-12,17H,1-4,9-10H2,(H,18,19) |
PubChem CID | 10446240 |
ChEMBL | CHEMBL203263 |
IUPHAR | N/A |
BindingDB | 85830 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | -0.97 - | PMID16610798 | ChEMBL |
IC50 | 1.259 nM | PMID16610798 | ChEMBL |
IC50 | 1.3 nM | PMID16610798 | BindingDB |
Ki | 2.34 nM | PMID11714875 | BindingDB |
Ki | 2.512 nM | PMID16610798 | ChEMBL |
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