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GPCR

NameMu-type opioid receptor
SpeciesBos taurus (Bovine)
GeneOPRM1
SynonymM-OR-1
MOR-1
DiseaseN/A for non-human GPCRs
Length401
Amino acid sequenceMDSGAVPTNASNCTDPFTHPSSCSPAPSPSSWVNFSHLEGNLSDPCGPNRTELGGSDRLCPSAGSPSMITAIIIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDLRTPRNAKIINICNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPILIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETTPLP
UniProtP79350
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3041
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL301421
Molecular formulaC17H25NO
IUPAC name10-(dimethylamino)-1,9-dimethyltricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol
Molecular weight259.393
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP3.8
SynonymsBDBM50050478
10-Dimethylamino-1,9-dimethyl-tricyclo[7.3.1.0*2,7*]trideca-2,4,6-trien-4-ol
Inchi KeyPBLYKDHZSNMTDF-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H25NO/c1-16-8-7-15(18(3)4)17(2,11-16)10-12-5-6-13(19)9-14(12)16/h5-6,9,15,19H,7-8,10-11H2,1-4H3
PubChem CID44301534
ChEMBLCHEMBL301421
IUPHARN/A
BindingDB50050478
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki297.0 nMPMID8642554BindingDB,ChEMBL
Ki297.0 nMPMID8642554BindingDB
Ki2020.0 nMPMID8642554ChEMBL

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