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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	D(1A) dopamine receptor
Species	Bos taurus (Bovine)
Gene	DRD1
Synonym	Dopamine D1 receptor
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MRTLNTSTMEGTGLVAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTGPSEGNATSLGKTINNCDSSLSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKNCQTTTGNGNPMECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCGSGETKPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNVVYLIPHAVGSSEGLKKEEAVGIAKPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
UniProt	Q95136
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2967
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	UNII-NGJ1K8EOK1
Molecular formula	C21H26N4
IUPAC name	(6S)-2-phenyl-6-[(4-phenylpiperazin-1-yl)methyl]-1,4,5,6-tetrahydropyrimidine
Molecular weight	334.467
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	2.9
Synonyms	Pyrimidine, 3,4,5,6-tetrahydro-2-phenyl-4-((4-phenyl-1-piperazinyl)methyl)-, (4S)- NGJ1K8EOK1 (4S)-2-Phenyl-4alpha-(4-phenylpiperazinomethyl)-1,4,5,6-tetrahydropyrimidine 562104-72-7 CHEMBL169459 (+)-(6S)-3,4,5,6-Tetrahydro-2-phenyl-6-((4-phenyl-1-piperazinyl)methyl)pyrimidine Pyrimidine, 1,4,5,6-tetrahydro-2-phenyl-4-((4-phenyl-1-piperazinyl)methyl)-, (4S)- (S)-2-Phenyl-4-(4-phenyl-piperazin-1-ylmethyl)-1,4,5,6-tetrahydro-pyrimidine BDBM50124193 FAUC-312 (+)-Fauc-312 [ Show all ]
Inchi Key	BJWYIHWMKMZYRS-IBGZPJMESA-N
Inchi ID	InChI=1S/C21H26N4/c1-3-7-18(8-4-1)21-22-12-11-19(23-21)17-24-13-15-25(16-14-24)20-9-5-2-6-10-20/h1-10,19H,11-17H2,(H,22,23)/t19-/m0/s1
PubChem CID	10359539
ChEMBL	CHEMBL169459
IUPHAR	N/A
BindingDB	50124193
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	39000.0 nM	PMID12617906	BindingDB,ChEMBL

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