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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	fMet-Leu-Phe receptor
Species	Homo sapiens (Human)
Gene	FPR1
Synonym	NFPR N-formylpeptide chemoattractant receptor N-formyl peptide receptor FPR1 FPR formyl peptide receptor 1 fMLP receptor fMLF-R [ Show all ]
Disease	Inflammatory disease Peptic ulcer
Length	350
Amino acid sequence	METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProt	P21462
Protein Data Bank	N/A
GPCR-HGmod model	P21462
3D structure model	This predicted structure model is from GPCR-EXP P21462.
BioLiP	N/A
Therapeutic Target Database	T87831
ChEMBL	CHEMBL3359
IUPHAR	222
DrugBank	BE0000995

Ligand

Name	MLS000047151
Molecular formula	C11H10N2O4S2
IUPAC name	methyl 1-(2,1,3-benzothiadiazol-4-ylsulfonyl)cyclopropane-1-carboxylate
Molecular weight	298.331
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	1.3
Synonyms	methyl 1-(2,1,3-benzothiadiazol-4-ylsulfonyl)cyclopropane-1-carboxylate SMR000033162 1-(2,1,3-benzothiadiazol-4-ylsulfonyl)-1-cyclopropanecarboxylic acid methyl ester EU-0032777 AC1MMTR6 methyl 1-(2,1,3-benzothiadiazol-4-ylsulfonyl)cyclopropanecarboxylate CHEMBL1456551 1-piazthiol-4-ylsulfonylcyclopropanecarboxylic acid methyl ester HMS2278L19 BDBM37742 cid_3244290 [ Show all ]
Inchi Key	BJRKOTLNYXDXHI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H10N2O4S2/c1-17-10(14)11(5-6-11)19(15,16)8-4-2-3-7-9(8)13-18-12-7/h2-4H,5-6H2,1H3
PubChem CID	3244290
ChEMBL	CHEMBL1456551
IUPHAR	N/A
BindingDB	37742
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<66700.0 nM	N/A	BindingDB
Ki	<43700.0 nM	N/A	BindingDB
Ki	<66700.0 nM	PubChem BioAssay data set	ChEMBL

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