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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Alpha-2B adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra2b
Synonym	ADRA2L1 alpha2B-adrenoceptor alpha2B alpha2-C2 alpha-2BAR alpha-2B adrenoreceptor Alpha-2B adrenoceptor Adra-2b adrenergic receptor Adrenergic alpha2B- receptor class III ADRA2RL1 alpha-2B adrenergic receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	453
Amino acid sequence	MSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPRGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPQPVAGGVPTSAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPTWSALPRSGQGQKKGTSGATAEEGDEEDEEEVEECEPQTLPASPASVCNPPLQQPQTSRVLATLRGQVLLGKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRILCRPWTQTGW
UniProt	P19328
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL266
IUPHAR	26
DrugBank	N/A

Ligand

Name	4-Chloro-2-(2-imidazolin-2-ylamino)isoindoline
Molecular formula	C11H13ClN4
IUPAC name	4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-1,3-dihydroisoindol-2-amine
Molecular weight	236.703
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	1.0
Synonyms	4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-1,3-dihydroisoindol-2-amine CHEMBL1162356 AC1L2YWU PDSP1_001653 BDF6143 ZINC6093764 76727-72-5 CTK5E3355 2H-Isoindol-2-amine,4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-1,3-dihydro-, hydrochloride (1:1) BDBM50179397 PDSP2_001637 4-Chloro-2-[(2-imidazolin-2-yl)amino]isoindoline CAS_76727-72-5 KB-241136 4-chloro-2-(2-imidazolin-2-ylamino)-isoindoline BDBM81804 SCHEMBL8091334 [ Show all ]
Inchi Key	OYLPBTPLAUXYTB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H13ClN4/c12-10-3-1-2-8-6-16(7-9(8)10)15-11-13-4-5-14-11/h1-3H,4-7H2,(H2,13,14,15)
PubChem CID	131284
ChEMBL	N/A
IUPHAR	N/A
BindingDB	81804
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	0.14 nM	PMID1656026	BindingDB

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