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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	C-C chemokine receptor type 3
Species	Homo sapiens (Human)
Gene	CCR3
Synonym	MIP-1alphaRL-2 (mouse) Eosinophil eotaxin receptor CKR3 chemokine (C-C motif) receptor 3 CD193 CCR3 CCR-3 CC-CKR-3 CC CKR3 C-C CKR-3 [ Show all ]
Disease	Allergic asthma Allergic rhinitis Asthma
Length	355
Amino acid sequence	MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
UniProt	P51677
Protein Data Bank	N/A
GPCR-HGmod model	P51677
3D structure model	This predicted structure model is from GPCR-EXP P51677.
BioLiP	N/A
Therapeutic Target Database	T02752, T85228
ChEMBL	CHEMBL3473
IUPHAR	60
DrugBank	N/A

Ligand

Name	CHEMBL193354
Molecular formula	C28H32Cl2N4O
IUPAC name	N-[[1-[1-[(3,4-dichlorophenyl)methyl]piperidin-4-yl]piperidin-3-yl]methyl]quinoline-8-carboxamide
Molecular weight	511.491
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	5.6
Synonyms	SCHEMBL18840773 BDBM50167454 Quinoline-8-carboxylic acid [1''-(3,4-dichloro-benzyl)-[1,4'']bipiperidinyl-3-ylmethyl]-amide
Inchi Key	BJNIWMAHXDJWJS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H32Cl2N4O/c29-25-9-8-20(16-26(25)30)18-33-14-10-23(11-15-33)34-13-3-4-21(19-34)17-32-28(35)24-7-1-5-22-6-2-12-31-27(22)24/h1-2,5-9,12,16,21,23H,3-4,10-11,13-15,17-19H2,(H,32,35)
PubChem CID	11540776
ChEMBL	CHEMBL193354
IUPHAR	N/A
BindingDB	50167454
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Emax	-7.0 %	PMID15908209	ChEMBL
Emax	128.0 %	PMID15908209	ChEMBL
Ki	30.0 nM	PMID15908209	BindingDB,ChEMBL
Ki	36.0 nM	PMID15908209	BindingDB,ChEMBL

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