You can:
Name | 5-hydroxytryptamine receptor 1A |
---|---|
Species | Homo sapiens (Human) |
Gene | HTR1A |
Synonym | 5-HT-1A 5-HT1A serotonin receptor 1A 5-HT1A receptor 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled [ Show all ] |
Disease | Urinary incontinence Generalized anxiety disorder Generalized anxiety disorder; Social phobia Hypertension Hypoactive sexual desire disorder [ Show all ] |
Length | 422 |
Amino acid sequence | MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ |
UniProt | P08908 |
Protein Data Bank | N/A |
GPCR-HGmod model | P08908 |
3D structure model | This predicted structure model is from GPCR-EXP P08908. |
BioLiP | N/A |
Therapeutic Target Database | T78709 |
ChEMBL | CHEMBL214 |
IUPHAR | 1 |
DrugBank | BE0000291 |
Name | piribedil |
---|---|
Molecular formula | C16H18N4O2 |
IUPAC name | 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine |
Molecular weight | 298.346 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 0 |
XlogP | 1.8 |
Synonyms | AC1Q6ZYE Piribedilum BC201086 Pyrimidine, 2-(4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)- BRN 0963637 [ Show all ] |
Inchi Key | OQDPVLVUJFGPGQ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C16H18N4O2/c1-4-17-16(18-5-1)20-8-6-19(7-9-20)11-13-2-3-14-15(10-13)22-12-21-14/h1-5,10H,6-9,11-12H2 |
PubChem CID | 4850 |
ChEMBL | CHEMBL1371770 |
IUPHAR | 49 |
BindingDB | 85092 |
DrugBank | DB12478 |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 398.107 nM | PMID12388666 | IUPHAR |
Ki | 446.68 nM | PMID12388666 | BindingDB |
Ki | 446.684 nM | PMID12388666 | PDSP |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417