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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	C-C chemokine receptor type 3
Species	Homo sapiens (Human)
Gene	CCR3
Synonym	MIP-1alphaRL-2 (mouse) Eosinophil eotaxin receptor CKR3 chemokine (C-C motif) receptor 3 CD193 CCR3 CCR-3 CC-CKR-3 CC CKR3 C-C CKR-3 [ Show all ]
Disease	Allergic asthma Allergic rhinitis Asthma
Length	355
Amino acid sequence	MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
UniProt	P51677
Protein Data Bank	N/A
GPCR-HGmod model	P51677
3D structure model	This predicted structure model is from GPCR-EXP P51677.
BioLiP	N/A
Therapeutic Target Database	T02752, T85228
ChEMBL	CHEMBL3473
IUPHAR	60
DrugBank	N/A

Ligand

Name	CHEMBL195657
Molecular formula	C31H41N3O
IUPAC name	2-(4-tert-butylphenyl)-N-[2-(2-methoxyphenyl)ethyl]-2-(4-phenylpiperazin-1-yl)ethanamine
Molecular weight	471.689
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	6.6
Synonyms	BDBM50162407 SCHEMBL18840921 [2-(4-tert-Butyl-phenyl)-2-(4-phenyl-piperazin-1-yl)-ethyl]-[2-(2-methoxy-phenyl)-ethyl]-amine
Inchi Key	BIKFSSUQPVPOTQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C31H41N3O/c1-31(2,3)27-16-14-25(15-17-27)29(24-32-19-18-26-10-8-9-13-30(26)35-4)34-22-20-33(21-23-34)28-11-6-5-7-12-28/h5-17,29,32H,18-24H2,1-4H3
PubChem CID	44401256
ChEMBL	CHEMBL195657
IUPHAR	N/A
BindingDB	50162407
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	488.0 nM	PMID15743194	ChEMBL
Ki	488.0 nM	PMID15743194	BindingDB

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