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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL216342
Molecular formula	C21H20ClN3O
IUPAC name	(E)-N-(4-amino-2-propylquinolin-6-yl)-3-(2-chlorophenyl)prop-2-enamide
Molecular weight	365.861
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	4.6
Synonyms	BDBM50193623 (E)-N-(4-amino-2-propylquinolin-6-yl)-3-(2-chlorophenyl)acrylamide
Inchi Key	BIDLIOISUBBYOB-DHZHZOJOSA-N
Inchi ID	InChI=1S/C21H20ClN3O/c1-2-5-15-13-19(23)17-12-16(9-10-20(17)24-15)25-21(26)11-8-14-6-3-4-7-18(14)22/h3-4,6-13H,2,5H2,1H3,(H2,23,24)(H,25,26)/b11-8+
PubChem CID	44417838
ChEMBL	CHEMBL216342
IUPHAR	N/A
BindingDB	50193623
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	500.0 nM	PMID16919453	BindingDB,ChEMBL
IC50	120.0 nM	PMID16919453	BindingDB,ChEMBL

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