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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 1D
Species	Cavia porcellus (Guinea pig)
Gene	HTR1D
Synonym	5-HT-1D 5-HT1D Serotonin receptor 1D
Disease	N/A for non-human GPCRs
Length	376
Amino acid sequence	MSPPNQSEEGLPQEASNRSLNATETPGDWDPGLLQALKVSLVVVLSIITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAGAMIAAVWVISICISIPPLFWRQAQAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYSRIYRAARSRILNPPSLSGKRFTTAHLITGSAGSSLCSLNPSLHEGHMHPGSPLFFNHVRIKLADSVLERKRISAARERKATKTLGIILGAFIVCWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEDFRQAFQKVVHFRKAS
UniProt	Q60484
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2304407
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	143797-63-1
Molecular formula	C15H14N4O
IUPAC name	1-(1-methylindol-5-yl)-3-pyridin-3-ylurea
Molecular weight	266.304
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	1.5
Synonyms	1-(1-methylindol-5-yl)-3-pyridin-3-ylurea CHEBI:8976 N-(1-Methyl-5-indolyl)-N'-(3-pyridyl)urea SB-200646 SB200646a AC1L2QVR DTXSID40162550 PDSP1_001636 Urea, N-(1-methyl-1H-indol-5-yl)-N'-3-pyridinyl- 1-(1-Methyl-1H-indol-5-yl)-3-(pyridin-3-yl)urea BRD-K77677632-003-01-8 N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea SB 200646 HCl SB-200646 hydrochloride NCGC00025128-01 SCHEMBL173735 AKOS027422836 L000535 PDSP2_001620 ZINC5475 1-(1-methylindol-5-yl)-3-(3-pyridyl)urea C11739 N-(1-methyl-5-indolyl)-N'-(3-pyridyl) urea SB 200646A SB200646 CHEMBL85194 NCGC00025128-02 Tocris-1371 BDBM82272 Mip-urea SB 200646 [ Show all ]
Inchi Key	OJZZJTLBYXHUSJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H14N4O/c1-19-8-6-11-9-12(4-5-14(11)19)17-15(20)18-13-3-2-7-16-10-13/h2-10H,1H3,(H2,17,18,20)
PubChem CID	126769
ChEMBL	CHEMBL85194
IUPHAR	N/A
BindingDB	82272
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID8788493	BindingDB

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