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GPCR

NameSubstance-K receptor
SpeciesOryctolagus cuniculus (Rabbit)
GeneTACR2
SynonymNeurokinin A receptor
NK-2 receptor
NK-2R
SKR
Tachykinin receptor 2
DiseaseN/A for non-human GPCRs
Length384
Amino acid sequenceMGACDIVTEANISSDIDSNATGVTAFSMPGWQLALWATAYLALVLVAVVGNATVIWIILAHRRMRTVTNYFIVNLALADLCMATFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSGPGTKAVIAGIWLVALALAFPQCFYSTITMDQGATKCVVAWPEDSGGKMLLLYHLTVIALIYFLPLVVMFVAYSVIGFKLWRRTVPGHQTHGANLRHLRAKKKFVKTMVLVVVTFAVCWLPYHLYFLLGHFQDDIYCRKFIQQVYLVLFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDKLELTHTPSLSVRVNRCHTKETLFLVGDVAPSEAANGQAGGPQDGGAYDF
UniProtP79218
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3433
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL2373189
Molecular formulaC34H36Cl2N2O2S
IUPAC nameN-[(2S)-2-(3,4-dichlorophenyl)-4-[4-(2-methylsulfinylphenyl)piperidin-1-yl]butyl]-N-methylnaphthalene-1-carboxamide
Molecular weight607.634
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP7.4
SynonymsN-Methyl-N-[(2S)-2-(3,4-dichlorophenyl)-4-[4-[2-(methylsulfinyl)phenyl]piperidino]butyl]naphthalene-1-carboxamide
Inchi KeyBHYOUSXFDYYCRF-YTAZJQBPSA-N
Inchi IDInChI=1S/C34H36Cl2N2O2S/c1-37(34(39)30-12-7-9-24-8-3-4-10-28(24)30)23-27(26-14-15-31(35)32(36)22-26)18-21-38-19-16-25(17-20-38)29-11-5-6-13-33(29)41(2)40/h3-15,22,25,27H,16-21,23H2,1-2H3/t27-,41?/m1/s1
PubChem CID73345760
ChEMBLCHEMBL2373189
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
pKB8.18 -PMID11591520ChEMBL

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