You can:
Name | Histamine H3 receptor |
---|---|
Species | Cavia porcellus (Guinea pig) |
Gene | HRH3 |
Synonym | H3R HH3R |
Disease | N/A for non-human GPCRs |
Length | 445 |
Amino acid sequence | MERAPPDGLMNASGALAGEAAAAAGGARTFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMVLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGAREAGPDPLPEAQSSPPQPPPGCWGCWPKGQGESMPLHRYGVGEAGPGAEAGEAALGGGSGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHSSLEHCWK |
UniProt | Q9JI35 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5076 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL44220 |
---|---|
Molecular formula | C10H18N4S |
IUPAC name | 1-[5-(1H-imidazol-5-yl)pentyl]-3-methylthiourea |
Molecular weight | 226.342 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 3 |
XlogP | 0.8 |
Synonyms | N-[5-(1H-Imidazol-4-yl)pentyl]-N'-methylthiourea 1-[5-(1H-imidazol-5-yl)pentyl]-3-methylthiourea AC1NQNAJ SCHEMBL11110967 34042-45-0 [ Show all ] |
Inchi Key | BHXVXFKQYAHZKJ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C10H18N4S/c1-11-10(15)13-6-4-2-3-5-9-7-12-8-14-9/h7-8H,2-6H2,1H3,(H,12,14)(H2,11,13,15) |
PubChem CID | 5250783 |
ChEMBL | CHEMBL44220 |
IUPHAR | N/A |
BindingDB | 50407372 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Kd | 10.0 nM | PMID7783156, PMID11356102 | BindingDB,ChEMBL |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417