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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Neuropeptide Y receptor type 5
Species	Homo sapiens (Human)
Gene	NPY5R
Synonym	NPYY5-R NPY5-R NPY-Y5 receptor neuropeptide Y receptor type 5 food intake receptor Y5 receptor [ Show all ]
Disease	Eating disorder; Obesity Eating disorder; Obesity; Diabetes Major depressive disorder Obesity
Length	445
Amino acid sequence	MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
UniProt	Q15761
Protein Data Bank	N/A
GPCR-HGmod model	Q15761
3D structure model	This predicted structure model is from GPCR-EXP Q15761.
BioLiP	N/A
Therapeutic Target Database	T20331
ChEMBL	CHEMBL4561
IUPHAR	308
DrugBank	N/A

Ligand

Name	CHEMBL119726
Molecular formula	C22H27N3O2
IUPAC name	N-(2,4-dimethyl-9-propan-2-ylcarbazol-3-yl)morpholine-4-carboxamide
Molecular weight	365.477
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.6
Synonyms	BDBM50116599 Morpholine-4-carboxylic acid (9-isopropyl-2,4-dimethyl-9H-carbazol-3-yl)-amide SCHEMBL6829168
Inchi Key	BHTJQQZHOZWIRO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H27N3O2/c1-14(2)25-18-8-6-5-7-17(18)20-16(4)21(15(3)13-19(20)25)23-22(26)24-9-11-27-12-10-24/h5-8,13-14H,9-12H2,1-4H3,(H,23,26)
PubChem CID	11035908
ChEMBL	CHEMBL119726
IUPHAR	N/A
BindingDB	50116599
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	390.0 nM	PMID12139462	BindingDB,ChEMBL

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