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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Sus scrofa (Pig)
Gene	HTR2A
Synonym	5-HT-2 5-HT-2A 5-HT2A Serotonin receptor 2A
Disease	N/A for non-human GPCRs
Length	470
Amino acid sequence	MDVLCEENTSLSSPTNSFMQLNDDTRLYHNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHRRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQTGQKENSKQDDKATENDCTMVALGKQHSEDAPADNSNTVNEKVSCV
UniProt	P50129
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2490
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL1923292
Molecular formula	C19H21FN2O2
IUPAC name	1-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-[(4-fluorophenyl)methyl]piperazine
Molecular weight	328.387
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	3.2
Synonyms	1-(1,4 benzodioxan-6-yl)-4-(4-fluorobenzyl) piperazine BDBM50358838 OEFFTIMBYVFOPK-UHFFFAOYSA-N 1-(1,4 benzodioxan-6-yl)-4-(4-fluorobenzyl)piperazine SCHEMBL7527827
Inchi Key	OEFFTIMBYVFOPK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H21FN2O2/c20-16-3-1-15(2-4-16)14-21-7-9-22(10-8-21)17-5-6-18-19(13-17)24-12-11-23-18/h1-6,13H,7-12,14H2
PubChem CID	9797495
ChEMBL	CHEMBL1923292
IUPHAR	N/A
BindingDB	50358838
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	7000.0 nM	PMID22039961	BindingDB,ChEMBL

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