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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(1A) dopamine receptor
Species	Mus musculus (Mouse)
Gene	Drd1
Synonym	D1 receptor D1A DADR Dopamine D1 receptor Dopamine-1A receptor Gpcr15 [ Show all ]
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MAPNTSTMDETGLPVERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDAEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTTGNGNPVECSQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVMFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKREEAGGIPKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
UniProt	Q61616
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3071
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	FLUPERLAPINE
Molecular formula	C19H20FN3
IUPAC name	3-fluoro-6-(4-methylpiperazin-1-yl)-11H-benzo[c][1]benzazepine
Molecular weight	309.388
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	2.9
Synonyms	NB-106689 PDSP2_000470 UNII-EWG253M961 BRD-K15715913-001-01-5 CTK8F9821 Fluperlapina [INN-Spanish] HMS2052M07 NCGC00160388-02 SMR000449303 3-Fluoro-6-(4-methyl-piperazin-1-yl)-11H-dibenzo[b,e]azepine AC1L2LPB CCG-101093 DSSTox_GSID_46123 Fluperlapinum L000256 MLS001424156 OBWGMKKHCLHVIE-UHFFFAOYSA-N Tox21_111780 3-fluoro-6-(4-methylpiperazin-1-yl)-11H-benzo[c][1]benzazepine Biomol-NT_000093 CHEMBL63756 EWG253M961 FT-0651061 NC00343 SAM001247034 ZINC26247473 67121-76-0 C10967 D0F8TG HMS2090H12 NCGC00160388-03 SR-01000759288 3-Fluoro-6-(4-methyl-piperazin-1-yl)-11H-dibenzo[b,e]azepine(fluperlapine) API0006718 CHEBI:5122 DSSTox_RID_81359 Fluperlapinum [INN-Latin] LS-176575 NB 106-689 PDSP1_000472 Tox21_111780_1 (E)-3-fluoro-6-(4-methylpiperazin-1-yl)-11H-dibenzo[b,e]azepine 3-fluoro-6-(4-methylpiperazinyl)-11H-dibenz(b,e)azepine BPBio1_001099 CPD000449303 Fluperlapina GTPL279 NCGC00160388-01 SCHEMBL142558 3-Fluoro-6-(4-methyl-1-piperazinyl)morphanthridine AB00639914-06 CAS-67121-76-0 DSSTox_CID_26123 Fluperlapine [INN] HMS3394M07 NCGC00160388-04 SR-01000759288-4 3-fluoro-6-(4-methyl-piperazinyl)-11h-dibenz-(b,e)-azepine BDBM50040241 DTXSID2046123 FT-0081219 MLS000758217 [ Show all ]
Inchi Key	OBWGMKKHCLHVIE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H20FN3/c1-22-8-10-23(11-9-22)19-17-5-3-2-4-14(17)12-15-6-7-16(20)13-18(15)21-19/h2-7,13H,8-12H2,1H3
PubChem CID	49381
ChEMBL	CHEMBL63756
IUPHAR	279
BindingDB	50040241
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	85.0 nM	PMID2895008	BindingDB

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