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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(4) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD4
Synonym	D4 receptor D4R Dopamine D4 receptor dopamine receptor 4 d(2C) dopamine receptor
Disease	Erectile dysfunction Psychotic disorders Schizophrenia
Length	467
Amino acid sequence	MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
UniProt	P21917
Protein Data Bank	5wiv, 5wiu
GPCR-HGmod model	P21917
3D structure model	This structure is from PDB ID 5wiv.
BioLiP	BL0394824, BL0394826, BL0394825
Therapeutic Target Database	T24983
ChEMBL	CHEMBL219
IUPHAR	217
DrugBank	BE0009376, BE0000389

Ligand

Name	FLUPERLAPINE
Molecular formula	C19H20FN3
IUPAC name	3-fluoro-6-(4-methylpiperazin-1-yl)-11H-benzo[c][1]benzazepine
Molecular weight	309.388
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	2.9
Synonyms	API0006718 CHEBI:5122 DSSTox_RID_81359 Fluperlapinum [INN-Latin] LS-176575 NCGC00160388-03 SR-01000759288 3-Fluoro-6-(4-methyl-piperazin-1-yl)-11H-dibenzo[b,e]azepine(fluperlapine) 3-fluoro-6-(4-methylpiperazinyl)-11H-dibenz(b,e)azepine BPBio1_001099 CPD000449303 Fluperlapina GTPL279 NB 106-689 PDSP1_000472 Tox21_111780_1 (E)-3-fluoro-6-(4-methylpiperazin-1-yl)-11H-dibenzo[b,e]azepine AB00639914-06 CAS-67121-76-0 DSSTox_CID_26123 Fluperlapine [INN] HMS3394M07 NCGC00160388-01 SCHEMBL142558 3-Fluoro-6-(4-methyl-1-piperazinyl)morphanthridine 3-fluoro-6-(4-methyl-piperazinyl)-11h-dibenz-(b,e)-azepine BDBM50040241 DTXSID2046123 FT-0081219 MLS000758217 NCGC00160388-04 SR-01000759288-4 BRD-K15715913-001-01-5 CTK8F9821 Fluperlapina [INN-Spanish] HMS2052M07 NB-106689 PDSP2_000470 UNII-EWG253M961 AC1L2LPB CCG-101093 DSSTox_GSID_46123 Fluperlapinum L000256 NCGC00160388-02 SMR000449303 3-Fluoro-6-(4-methyl-piperazin-1-yl)-11H-dibenzo[b,e]azepine 3-fluoro-6-(4-methylpiperazin-1-yl)-11H-benzo[c][1]benzazepine Biomol-NT_000093 CHEMBL63756 EWG253M961 FT-0651061 MLS001424156 OBWGMKKHCLHVIE-UHFFFAOYSA-N Tox21_111780 67121-76-0 C10967 D0F8TG HMS2090H12 NC00343 SAM001247034 ZINC26247473 [ Show all ]
Inchi Key	OBWGMKKHCLHVIE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H20FN3/c1-22-8-10-23(11-9-22)19-17-5-3-2-4-14(17)12-15-6-7-16(20)13-18(15)21-19/h2-7,13H,8-12H2,1H3
PubChem CID	49381
ChEMBL	CHEMBL63756
IUPHAR	279
BindingDB	50040241
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	21.0 nM	PMID9577836	PDSP,BindingDB

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