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Name | Prostaglandin E2 receptor EP2 subtype |
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Species | Rattus norvegicus (Rat) |
Gene | Ptger2 |
Synonym | EP2 receptor PGE receptor EP2 subtype PGE2 receptor EP2 subtype prostaglandin E receptor 2 (subtype EP2), 53kDa Prostanoid EP2 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 357 |
Amino acid sequence | MDNSFNDSRRVENCESRQYLLSDESPAISSVMFTAGVLGNLIALALLARRWRGDTGCSAGSRTSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQTLVALAPESRACTYFAFTMTFFSLATMLMLFAMALERYLAIGHPYFYRRRVSRRGGLAVLPAIYGVSLLFCSLPLLNYGEYVQYCPGTWCFIQHGRTAYLQLYATVLLLLIVAVLGCNISVILNLIRMQLRSKRSRCGLSGSSLRGPGSRRRGERTSMAEETDHLILLAIMTITFAVCSLPFTIFAYMDETSSRKEKWDLRALRFLSVNSIIDPWVFVILRPPVLRLMRSVLCCRTSLRAPEAPGASCSTQQTDLCGQL |
UniProt | Q62928 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4909 |
IUPHAR | 341 |
DrugBank | N/A |
Name | CHEMBL2036320 |
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Molecular formula | C28H30N2O4S2 |
IUPAC name | 2-[2-[(2R)-2-[(E,3S)-4-[3-(2,4-dimethylphenyl)phenyl]-3-hydroxybut-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid |
Molecular weight | 522.678 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 2 |
XlogP | 5.2 |
Synonyms | BDBM50385130 SCHEMBL14270372 |
Inchi Key | OAAKRDFPYNRCLP-DKARNCPTSA-N |
Inchi ID | InChI=1S/C28H30N2O4S2/c1-18-6-10-24(19(2)14-18)21-5-3-4-20(15-21)16-23(31)9-7-22-8-11-26(32)30(22)12-13-35-28-29-25(17-36-28)27(33)34/h3-7,9-10,14-15,17,22-23,31H,8,11-13,16H2,1-2H3,(H,33,34)/b9-7+/t22-,23+/m0/s1 |
PubChem CID | 10414412 |
ChEMBL | CHEMBL2036320 |
IUPHAR | N/A |
BindingDB | 50385130 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | <10000.0 nM | PMID22546206 | BindingDB,ChEMBL |
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