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GPCR

NameNeuropeptides B/W receptor type 1
SpeciesHomo sapiens (Human)
GeneNPBWR1
SynonymG protein-coupled receptor 7
G-protein coupled receptor 7
GPR7
neuropeptides B/W receptor type 1
NPBW1 receptor
DiseaseN/A
Length328
Amino acid sequenceMDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
UniProtP48145
Protein Data BankN/A
GPCR-HGmod modelP48145
3D structure modelThis predicted structure model is from GPCR-EXP P48145.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1293293
IUPHARN/A
DrugBankN/A

Ligand

NameSR-02000000428
Molecular formulaC21H22N2O3
IUPAC name4-(4-methoxyphenoxy)-5-methyl-2-(4-propan-2-ylphenyl)pyridazin-3-one
Molecular weight350.418
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP4.2
SynonymsBDBM75906
cid_46835794
4-(4-methoxyphenoxy)-5-methyl-2-p-cumenyl-pyridazin-3-one
4-(4-methoxyphenoxy)-5-methyl-2-(4-propan-2-ylphenyl)-3-pyridazinone
CHEMBL1716381
[ Show all ]
Inchi KeyBGWRLXAKBUUMEC-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H22N2O3/c1-14(2)16-5-7-17(8-6-16)23-21(24)20(15(3)13-22-23)26-19-11-9-18(25-4)10-12-19/h5-14H,1-4H3
PubChem CID46835794
ChEMBLCHEMBL1716381
IUPHARN/A
BindingDB75906
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC507500.0 nM, PubChem BioAssay data set, PMID23079522BindingDB,ChEMBL

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