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GLASS

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GPCR

Name	D(1B) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD5
Synonym	Gpcr1 DRD1L2 DRD1B dopamine receptor 5 Dopamine D5 receptor D5 receptor D1beta dopamine receptor D(5) dopamine receptor D(1B) dopamine receptor [ Show all ]
Disease	Solid tumours Schizophrenia
Length	477
Amino acid sequence	MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
UniProt	P21918
Protein Data Bank	N/A
GPCR-HGmod model	P21918
3D structure model	This predicted structure model is from GPCR-EXP P21918.
BioLiP	N/A
Therapeutic Target Database	T46828
ChEMBL	CHEMBL1850
IUPHAR	218
DrugBank	BE0000145, BE0004889

Ligand

Name	sulpiride
Molecular formula	C15H23N3O4S
IUPAC name	N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
Molecular weight	341.426
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	0.6
Synonyms	BPBio1_000233 SMR000038923 Lopac0_001050 C15H23N3O4S STK368596 MFCD00055061 Sulpiride [USAN:INN:BAN:JAN] N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide DB00391 Sulpiridum [INN-Latin] Dolmatil Tox21_302205 (+/-)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide NCGC00015966-05 EINECS 239-753-7 (y)-Sulpiride NCGC00255813-01 FT-0652244 5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-benzamide o-ANISAMIDE, N-((1-ETHYL-2-PYRROLIDINYL)METHYL)-5-SULFAMOYL-, (S)-(-)- HMS3371P16 Aiglonyl Prestwick3_000056 IDI1_000278 Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy- RD 1403 L000579 S 8010 Levosulpirida [INN-Spanish] BRD-A55272860-001-03-9 SR-01000075402 LS-20059 CCG-205127 Sulpirida Misulvan CS-4534 Sulpiride, SLP N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide dl-sulpiride Sulpride ( inverted question mark)-Sulpiride DSSTox_GSID_42574 Z84655412 (?)-Sulpiride NCGC00015966-08 EU-0001755 NINDS_000278 HMS1568K13 676S161 Oprea1_602476 HMS3651G12 AN-1017 PubChem17241 KB-295026 Benzamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoyl-, S-(-)- SCHEMBL8421 Levosulpiridum [INN-Latin] BRN 0494008 SR-01000075402-6 MCULE-7506797476 Championyl Sulpiride (JP17/USAN/INN) MolPort-002-070-475 Darleton Sulpiride-R Dogmatyl Sursumid (+/-)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide NCGC00015966-03 Eglonil (RS)-(+/-)-sulpiride NCGC00024852-04 Fardalan 5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide Nufarol HMS3263A22 AC-12181 Prestwick1_000056 HY-B1019 BCP13871 R. D. 1403 Kylistro Biomol-NT_000037 BPBio1_000463 SPBio_002132 LP01050 Calmoflorine Sulperide Miradol CHEMBL26 Sulpiride, British Pharmacopoeia (BP) Reference Standard N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide Desmenat Sulpitil Dresent Tox21_501050 (+/-)-Sulpiride NCGC00015966-06 Enimon NCGC00261735-01 GTPL5501 5-22-08-00105 (Beilstein Handbook Reference) Omiryl HMS3372O01 AKOS004912732 Prestwick_431 Isnamide Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-, (S)- Restful Levopraid S0501 Levosulpiride [INN] BRD-A55272860-001-04-7 SR-01000075402-2 Magnetic resonance imaging sulpiride CCRIS 4248 Sulpirida [INN-Spanish] MLS000069434 CTK8F2082 SULPIRIDE,(+) N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide Dobren Sulpyrid (+)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide DSSTox_RID_80050 Zemorcon (plusmn)-sulpiride NCGC00024852-02 EU-0101050 15676-16-1 Norestran HMS2095K13 AB0105833 Ozoderpin HMS3712K13 AN-1019 Pyrikappl KBio1_000278 Benzamide,5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy- Biomol-NT_000162 Sernevin Lisopiride BSPBio_000211 Stamonevrol Meresa CHEBI:32168 Sulpiride 1.0 mg/ml in Methanol N-(((S)-1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide Sulpiridum Dogmatyl (TN) Synedil (+/-)-N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide NCGC00015966-04 Eglonyl (RS)-(A+/-)-Sulpiride NCGC00024852-05 Fidelan 5-(Aminosulfonyl)-N-[(1-ethyl-2- pyrrolidinyl)methyl]-2-methoxy- benzamide o-Anisamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl- HMS3266P12 AC1L1K62 Prestwick2_000056 I06-0054 BDBM11638 R.D. 1403 L-Sulpiride BPBio1_001255 Splotin LS-20058 CAS-15676-16-1 Sulpirid Mirbanil Coolspan Sulpiride, European Pharmacopoeia (EP) Reference Standard N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoyl-benzamide DivK1c_000278 Sulpor ( inverted question mark)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide DSSTox_CID_22574 Valirem (.+/-.)-Sulpiride NCGC00015966-07 Equilid 1-ethyl-2-(2-methoxy-5-sulfamoylbenzamidomethyl)pyrrolidine Neogama Guastil Omperan HMS3393A08 Alimoral Psicocen J10067 Benzamide, 5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy- RV-12309 Levosulpirida s4655 Levosulpiridum BRD-A55272860-001-08-8 SR-01000075402-3 Mariastel CCRIS-4248 MLS001306443 D01226 SULPIRIDE,(-) Dogmatil Suprium (+-)-sulpiride N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide DTXSID1042574 (RS)-(+/-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide NCGC00024852-03 Eusulpid 5-(Aminosufonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide Normum HMS2231K07 Abilit Prestwick0_000056 HMS500N20 BCP04500 Pyrkappl KS-00000YBQ BGRJTUBHPOOWDU-UHFFFAOYSA-N [ Show all ]
Inchi Key	BGRJTUBHPOOWDU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)
PubChem CID	5355
ChEMBL	CHEMBL26
IUPHAR	5501
BindingDB	11638
DrugBank	DB00391
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID1826762	PDSP,BindingDB

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