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GPCR

NameMuscarinic acetylcholine receptor M5
SpeciesRattus norvegicus (Rat)
GeneChrm5
Synonymcholinergic receptor
cholinergic receptor, muscarinic 5
M5 receptor
M5R
DiseaseN/A for non-human GPCRs
Length531
Amino acid sequenceMEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPPDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEAKKREPAQRTLLRSFFSCPRPSLAQRERNQASWSSSRRSTSTTGKTTQATDLSADWEKAEQVTTCSSYPSSEDEAKPTTDPVFQMVYKSEAKESPGKESNTQETKETVVNTRTENSDYDTPKYFLSPAAAHRLKSQKCVAYKFRLVVKADGTQETNNGCRKVKIMPCSFPVSKDPSTKGPDPNLSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYWQGNSKLP
UniProtP08911
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL277
IUPHAR17
DrugBankN/A

Ligand

NameCHEMBL1916235
Molecular formulaC19H33N3O3
IUPAC nameethyl 4-[(3R)-3-(cyclopentanecarbonylamino)piperidin-1-yl]piperidine-1-carboxylate
Molecular weight351.491
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP2.5
SynonymsBDBM50356973
SCHEMBL1619986
Inchi KeyNTSQDFWSCSUPSQ-MRXNPFEDSA-N
Inchi IDInChI=1S/C19H33N3O3/c1-2-25-19(24)21-12-9-17(10-13-21)22-11-5-8-16(14-22)20-18(23)15-6-3-4-7-15/h15-17H,2-14H2,1H3,(H,20,23)/t16-/m1/s1
PubChem CID46873656
ChEMBLCHEMBL1916235
IUPHARN/A
BindingDB50356973
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50<10000.0 nMPMID21930376BindingDB,ChEMBL

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