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GPCR

NameMetabotropic glutamate receptor 3
SpeciesHomo sapiens (Human)
GeneGRM3
SynonymGPRC1C
mGluR3
mGlu3 receptor
glutamate receptor
DiseaseAlzheimer disease; Major depressive disorder
Anxiety disorder
Schizophrenia
Length879
Amino acid sequenceMKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL
UniProtQ14832
Protein Data Bank3sm9, 6b7h, 4xar, 5cnk, 5cnm
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 3sm9.
BioLiPBL0324562, BL0307715, BL0204618, BL0324563, BL0412294, BL0412295, BL0324561
Therapeutic Target DatabaseT02719
ChEMBLCHEMBL2888
IUPHAR291
DrugBankN/A

Ligand

NameCHEMBL330097
Molecular formulaC8H11NO5
IUPAC name(2R,3R,6S)-2-amino-3-hydroxybicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Molecular weight201.178
Hydrogen bond acceptor6
Hydrogen bond donor4
XlogP-3.7
SynonymsBDBM50089895
2-Amino-3-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid(HYDIA)
Inchi KeyNTPXNEQCDPWJQA-SJFCMNACSA-N
Inchi IDInChI=1S/C8H11NO5/c9-8(7(13)14)3(10)1-2-4(5(2)8)6(11)12/h2-5,10H,1,9H2,(H,11,12)(H,13,14)/t2?,3-,4+,5?,8+/m1/s1
PubChem CID44322840
ChEMBLCHEMBL330097
IUPHARN/A
BindingDB50089895
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki100.0 nMPMID10893301BindingDB,ChEMBL

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