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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H3 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH3
Synonym	H3R HH3R
Disease	N/A for non-human GPCRs
Length	445
Amino acid sequence	MERAPPDGLMNASGALAGEAAAAAGGARTFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMVLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGAREAGPDPLPEAQSSPPQPPPGCWGCWPKGQGESMPLHRYGVGEAGPGAEAGEAALGGGSGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHSSLEHCWK
UniProt	Q9JI35
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5076
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL105495
Molecular formula	C17H25ClN4O2S
IUPAC name	N-[(4-chlorophenyl)methylsulfamoyl]-7-(1H-imidazol-5-yl)heptan-1-amine
Molecular weight	384.923
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	3.5
Synonyms	BDBM50217242
Inchi Key	BGMIWORIAHINBP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H25ClN4O2S/c18-16-9-7-15(8-10-16)12-22-25(23,24)21-11-5-3-1-2-4-6-17-13-19-14-20-17/h7-10,13-14,21-22H,1-6,11-12H2,(H,19,20)
PubChem CID	44335873
ChEMBL	CHEMBL105495
IUPHAR	N/A
BindingDB	50217242
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	7.079 nM	PMID10560733	ChEMBL
Ki	7.1 nM	PMID10560733	BindingDB
pKB	8.37 -	PMID10560733	ChEMBL

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