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Name | C-C chemokine receptor type 3 |
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Species | Homo sapiens (Human) |
Gene | CCR3 |
Synonym | MIP-1alphaRL-2 (mouse) Eosinophil eotaxin receptor CKR3 chemokine (C-C motif) receptor 3 CD193 [ Show all ] |
Disease | Allergic asthma Allergic rhinitis Asthma |
Length | 355 |
Amino acid sequence | MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF |
UniProt | P51677 |
Protein Data Bank | N/A |
GPCR-HGmod model | P51677 |
3D structure model | This predicted structure model is from GPCR-EXP P51677. |
BioLiP | N/A |
Therapeutic Target Database | T02752, T85228 |
ChEMBL | CHEMBL3473 |
IUPHAR | 60 |
DrugBank | N/A |
Name | CHEMBL564022 |
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Molecular formula | C29H29ClFN3O3 |
IUPAC name | 2-[1-(4-chloro-2-hydroxybenzoyl)piperidin-4-ylidene]-N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]acetamide |
Molecular weight | 522.017 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 2 |
XlogP | 5.0 |
Synonyms | 2-[1-(4-Chloro-2-hydroxybenzoyl)piperidin-4-ylidene]-N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]pyrrolidin-3-yl}acetamide BDBM50297173 |
Inchi Key | ADGYFBWBQIOUQC-RUZDIDTESA-N |
Inchi ID | InChI=1S/C29H29ClFN3O3/c30-23-4-6-26(27(35)16-23)29(37)34-11-7-19(8-12-34)14-28(36)32-25-9-10-33(18-25)17-20-1-2-22-15-24(31)5-3-21(22)13-20/h1-6,13-16,25,35H,7-12,17-18H2,(H,32,36)/t25-/m1/s1 |
PubChem CID | 45269320 |
ChEMBL | CHEMBL564022 |
IUPHAR | N/A |
BindingDB | 50297173 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 7.5 nM | PMID19620010 | BindingDB,ChEMBL |
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