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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL562537
Molecular formula	C24H18F3N3O3
IUPAC name	ethyl 6-[[4-[4-(trifluoromethyl)phenyl]benzoyl]amino]imidazo[1,2-a]pyridine-2-carboxylate
Molecular weight	453.421
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	5.7
Synonyms	ethyl 6-(4''-(trifluoromethyl)biphenyl-4-ylcarboxamido)imidazo[1,2-a]pyridine-2-carboxylate SCHEMBL4459886 ethyl 6-({[4'-(trifluoromethyl) [1,1'-biphenyl]-4-yl]carbonyl}-amino)imidazo[1,2-a]pyridine-2-carboxylate AABAPQXESPRCSA-UHFFFAOYSA-N ethyl 6-({[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]carbonyl}-amino)imidazo[1,2-a]pyridine-2-carboxylate BDBM50297046 [ Show all ]
Inchi Key	AABAPQXESPRCSA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H18F3N3O3/c1-2-33-23(32)20-14-30-13-19(11-12-21(30)29-20)28-22(31)17-5-3-15(4-6-17)16-7-9-18(10-8-16)24(25,26)27/h3-14H,2H2,1H3,(H,28,31)
PubChem CID	23120543
ChEMBL	CHEMBL562537
IUPHAR	N/A
BindingDB	50297046
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<1000.0 nM	PMID19615899	BindingDB,ChEMBL

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