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GLASS

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GPCR

Name	Metabotropic glutamate receptor 2
Species	Homo sapiens (Human)
Gene	GRM2
Synonym	mGluR2 mGlu2 receptor metabotropic glutamate receptor 2 GPRC1B glutamate receptor
Disease	Central nervous system disease Anxiety disorder Bipolar disorder Major depressive disorder Mood disorder Psychiatric disorder Schizophrenia Alzheimer disease; Major depressive disorder [ Show all ]
Length	872
Amino acid sequence	MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
UniProt	Q14416
Protein Data Bank	5cnj, 5kzn, 5kzq, 5cni, 4xas, 4xaq
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 5cnj.
BioLiP	BL0365442, BL0324559,BL0324560, BL0324557,BL0324558, BL0306697,BL0306698, BL0306695,BL0306696, BL0365443
Therapeutic Target Database	T62820
ChEMBL	CHEMBL5137
IUPHAR	290
DrugBank	N/A

Ligand

Name	MTEP
Molecular formula	C11H8N2S
IUPAC name	2-methyl-4-(2-pyridin-3-ylethynyl)-1,3-thiazole
Molecular weight	200.259
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	2.3
Synonyms	3-[2-(2-Methylthiazol-4-yl)ethynyl]pyridine CHEMBL292065 KB-274670 3-(2-(2-methylthiazol-4-yl)ethynyl)pyridine D09YDQ Pyridine, 3-[(2-methyl-4-thiazolyl)ethynyl]- 3-[(2-methyl-4-thiazolyl)ethynyl]pyridine BDBM50122758 GTPL3336 2-methyl-4-(pyridin-3-ylethynyl)thiazole 329205-68-7 CTK1B8867 mGluR5 Antagonist, MTEP 3-(2-Methyl-thiazol-4-ylethynyl)-pyridine ACN-027361 DTXSID30430775 SCHEMBL187254 3-[2-(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine IN1238 3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine D00JLE 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine API0006876 FCH3417361 ZINC1489321 [ Show all ]
Inchi Key	NRBNGHCYDWUVLC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H8N2S/c1-9-13-11(8-14-9)5-4-10-3-2-6-12-7-10/h2-3,6-8H,1H3
PubChem CID	9794218
ChEMBL	CHEMBL292065
IUPHAR	3336
BindingDB	50122758
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	>50.0 %	PMID20382541	ChEMBL

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